Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 1978006..1978557 Replicon chromosome
Accession NZ_CP077404
Organism Streptococcus mutans strain FDAARGOS 1458

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag I6L88_RS09775 Protein ID WP_002280073.1
Coordinates 1978006..1978284 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag I6L88_RS09780 Protein ID WP_002280072.1
Coordinates 1978285..1978557 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L88_RS09745 (I6L88_09745) 1974113..1974367 - 255 WP_002270995.1 Txe/YoeB family addiction module toxin -
I6L88_RS09750 (I6L88_09750) 1974360..1974626 - 267 WP_002270994.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
I6L88_RS09755 (I6L88_09755) 1974890..1976548 - 1659 WP_002280077.1 FtsK/SpoIIIE domain-containing protein -
I6L88_RS09760 (I6L88_09760) 1976555..1976965 - 411 WP_002280076.1 DUF961 family protein -
I6L88_RS09765 (I6L88_09765) 1976988..1977302 - 315 WP_000406626.1 hypothetical protein -
I6L88_RS09770 (I6L88_09770) 1977641..1977937 - 297 WP_231872042.1 hypothetical protein -
I6L88_RS09775 (I6L88_09775) 1978006..1978284 - 279 WP_002280073.1 type II toxin-antitoxin system YafQ family toxin Toxin
I6L88_RS09780 (I6L88_09780) 1978285..1978557 - 273 WP_002280072.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
I6L88_RS09785 (I6L88_09785) 1978709..1979422 + 714 WP_002280071.1 hypothetical protein -
I6L88_RS09790 (I6L88_09790) 1980187..1980549 + 363 WP_002280070.1 helix-turn-helix transcriptional regulator -
I6L88_RS09795 (I6L88_09795) 1980613..1981407 + 795 WP_018110241.1 ImmA/IrrE family metallo-endopeptidase -
I6L88_RS09800 (I6L88_09800) 1981427..1981789 - 363 WP_002280068.1 hypothetical protein -
I6L88_RS09805 (I6L88_09805) 1981877..1983427 - 1551 WP_002280067.1 DNA cytosine methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(7-68)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10924.78 Da        Isoelectric Point: 8.0384

>T207129 WP_002280073.1 NZ_CP077404:c1978284-1978006 [Streptococcus mutans]
MYQVKFTSAFKKSYKRIKKRGLEMTLLDEVIEKLRLGQTLEEKYRDHELKGNFVGFRECHIKPDWLLIYLIEDDILTLTL
ADTGSHADLFKM

Download         Length: 279 bp

>T207129 NZ_CP102891:c4710963-4710679 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCAGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9847.31 Da        Isoelectric Point: 5.0337

>AT207129 WP_002280072.1 NZ_CP077404:c1978557-1978285 [Streptococcus mutans]
MATVPTQIRIDETVKAQATSLFNDLGMDMSSAVNIFLRQCLLRGGLPFTVEVPNYSQKTLEALAEAKRISRDETVASYGN
LADLKKALEA

Download         Length: 273 bp

>AT207129 NZ_CP102891:c4711195-4710953 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References