Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | SmuAT/- |
| Location | 1959360..1960321 | Replicon | chromosome |
| Accession | NZ_CP077404 | ||
| Organism | Streptococcus mutans strain FDAARGOS 1458 | ||
Toxin (Protein)
| Gene name | smuT | Uniprot ID | A0A2J9QC39 |
| Locus tag | I6L88_RS09645 | Protein ID | WP_002267097.1 |
| Coordinates | 1959360..1959875 (+) | Length | 172 a.a. |
Antitoxin (Protein)
| Gene name | smuA | Uniprot ID | - |
| Locus tag | I6L88_RS09650 | Protein ID | WP_002267098.1 |
| Coordinates | 1959875..1960321 (+) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6L88_RS09620 (I6L88_09620) | 1954807..1955514 | + | 708 | WP_018110238.1 | MerR family transcriptional regulator | - |
| I6L88_RS09625 (I6L88_09625) | 1955550..1956542 | - | 993 | WP_002280090.1 | BtrH N-terminal domain-containing protein | - |
| I6L88_RS09630 (I6L88_09630) | 1956731..1957285 | - | 555 | Protein_1855 | PadR family transcriptional regulator | - |
| I6L88_RS09635 (I6L88_09635) | 1957598..1958344 | + | 747 | WP_002264862.1 | 23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB | - |
| I6L88_RS09640 (I6L88_09640) | 1958368..1959228 | + | 861 | WP_002267096.1 | DegV family protein | - |
| I6L88_RS09645 (I6L88_09645) | 1959360..1959875 | + | 516 | WP_002267097.1 | hypothetical protein | Toxin |
| I6L88_RS09650 (I6L88_09650) | 1959875..1960321 | + | 447 | WP_002267098.1 | hypothetical protein | Antitoxin |
| I6L88_RS09655 (I6L88_09655) | 1960318..1960512 | + | 195 | WP_002267099.1 | helix-turn-helix transcriptional regulator | - |
| I6L88_RS09660 (I6L88_09660) | 1960912..1961358 | + | 447 | WP_002262993.1 | 50S ribosomal protein L13 | - |
| I6L88_RS09665 (I6L88_09665) | 1961383..1961775 | + | 393 | WP_002262992.1 | 30S ribosomal protein S9 | - |
| I6L88_RS09670 (I6L88_09670) | 1961881..1963104 | - | 1224 | WP_002280089.1 | tyrosine-type recombinase/integrase | - |
| I6L88_RS09675 (I6L88_09675) | 1963159..1963431 | - | 273 | WP_002280088.1 | helix-turn-helix domain-containing protein | - |
| I6L88_RS09680 (I6L88_09680) | 1963543..1963875 | - | 333 | WP_002280087.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
| I6L88_RS09685 (I6L88_09685) | 1963862..1964167 | - | 306 | WP_002280086.1 | hypothetical protein | - |
| I6L88_RS09690 (I6L88_09690) | 1964224..1965279 | - | 1056 | WP_002271006.1 | phage tail tip lysozyme | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 172 a.a. Molecular weight: 19512.16 Da Isoelectric Point: 9.8653
>T207127 WP_002267097.1 NZ_CP077404:1959360-1959875 [Streptococcus mutans]
MFDLVVNLILLVIVIGGFVFLRFYADKKGKREYDERQLLMQKKAYTNAAWVVMGFNLVLVIWGEVLAKYISLSFAGTANL
FLIVGVFVCSSILNDAYFTARKNKKFLYVYAVIIAIQIFTVYQNWSQGSFGHDGHIYLTGEKAMSLLFILTFAVIFLVTA
YKTIQDKREGK
MFDLVVNLILLVIVIGGFVFLRFYADKKGKREYDERQLLMQKKAYTNAAWVVMGFNLVLVIWGEVLAKYISLSFAGTANL
FLIVGVFVCSSILNDAYFTARKNKKFLYVYAVIIAIQIFTVYQNWSQGSFGHDGHIYLTGEKAMSLLFILTFAVIFLVTA
YKTIQDKREGK
Download Length: 516 bp
>T207127 NZ_CP102891:4005087-4005305 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA
Antitoxin
Download Length: 149 a.a. Molecular weight: 17012.29 Da Isoelectric Point: 9.5767
>AT207127 WP_002267098.1 NZ_CP077404:1959875-1960321 [Streptococcus mutans]
MKMEKSNKQVIYDERQQQIQLKSYSLSFWFVMFILYFATFGKTDLLLNIAFWGGLVLNFCYSTLRGVGPFVDPRFGKIAK
IGRLAAVPLIFLGMLVFLVAIIMSILEHDSLRETITKCSYLGLSGFWLICMGASIVYRHYLDKKEADK
MKMEKSNKQVIYDERQQQIQLKSYSLSFWFVMFILYFATFGKTDLLLNIAFWGGLVLNFCYSTLRGVGPFVDPRFGKIAK
IGRLAAVPLIFLGMLVFLVAIIMSILEHDSLRETITKCSYLGLSGFWLICMGASIVYRHYLDKKEADK
Download Length: 447 bp
>AT207127 NZ_CP102891:4004686-4005060 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|