Detailed information of TA system TA207126

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 511929..512515
• Replicon: chromosome
• Accession: NZ_CP077404
• Organism: Streptococcus mutans strain FDAARGOS 1458

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: I6L88_RS02655
• Protein ID: WP_002265423.1
• Coordinates: 511929..512120 (+)
• Length: 64 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A0H5AQZ7
• Locus tag: I6L88_RS02660
• Protein ID: WP_002269450.1
• Coordinates: 512138..512515 (+)
• Length: 126 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6L88_RS02640 (I6L88_02640)	509973..510839	+	867	WP_002280231.1	type II CRISPR-associated endonuclease Cas1	-
I6L88_RS02645 (I6L88_02645)	510836..511180	+	345	WP_002263547.1	CRISPR-associated endonuclease Cas2	-
I6L88_RS02650 (I6L88_02650)	511170..511832	+	663	WP_002263546.1	type II-A CRISPR-associated protein Csn2	-
I6L88_RS02655 (I6L88_02655)	511929..512120	+	192	WP_002265423.1	type II toxin-antitoxin system HicA family toxin	Toxin
I6L88_RS02660 (I6L88_02660)	512138..512515	+	378	WP_002269450.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
I6L88_RS02665 (I6L88_02665)	512613..512906	-	294	WP_142366348.1	hypothetical protein	-
I6L88_RS02670 (I6L88_02670)	512985..513878	-	894	WP_002272311.1	LexA family transcriptional regulator IrvR	-
I6L88_RS02675 (I6L88_02675)	514194..514478	+	285	WP_002262720.1	helix-turn-helix transcriptional regulator	-
I6L88_RS02680 (I6L88_02680)	514641..516392	+	1752	WP_002279994.1	GbpC/Spa domain-containing protein	-
I6L88_RS09985	516522..516752	+	231	WP_018110186.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-61)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (5-107)

Sequences

Toxin

Protein

• Length: 64 a.a.
• Molecular weight: 7177.52 Da
• Isoelectric Point: 10.7089

>T207126 WP_002265423.1 NZ_CP077404:511929-512120 [Streptococcus mutans]
MPLTGKELARLAINNGWEEVRVRGSHHHFKKDGVPYIVTIPIHGNKVLKIGLEKKLLRDLNLL

Nucleotide

• Length: 192 bp

>T207126 NZ_CP102891:c2644601-2643279 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCACTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCGCCACTCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin

Protein

• Length: 126 a.a.
• Molecular weight: 14293.28 Da
• Isoelectric Point: 4.5628

>AT207126 WP_002269450.1 NZ_CP077404:512138-512515 [Streptococcus mutans]
MLKSYPAIFHKEEEGYWVEFPEFGGGTQGEDLEEAMKNARQMLESVLASYLDEGMKLPNPSEIRKLSVEDGFATMIQADP
NPYLKNNKAIRKNVTVPEWLVQLADRDQVNYSEVLTKALEKKLQL

Nucleotide

• Length: 378 bp

>AT207126 NZ_CP102891:c2644867-2644601 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0H5AQZ7