Detailed information of TA system TA207123

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pmenTA/darT(toxin)
• Location: 1927887..1929601
• Replicon: chromosome
• Accession: NZ_CP077399
• Organism: Aeromonas sp. FDAARGOS 1407

Toxin (Protein)

• Gene name: pmenT
• Uniprot ID: -
• Locus tag: I6L37_RS09330
• Protein ID: WP_216993857.1
• Coordinates: 1927887..1928540 (+)
• Length: 218 a.a.

Antitoxin (Protein)

• Gene name: pmenA
• Uniprot ID: -
• Locus tag: I6L37_RS09335
• Protein ID: WP_216993858.1
• Coordinates: 1928537..1929601 (+)
• Length: 355 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6L37_RS09310 (I6L37_09310)	1922941..1923129	+	189	WP_021138010.1	DUF3283 family protein	-
I6L37_RS09315 (I6L37_09315)	1923276..1923722	+	447	WP_043852095.1	hypothetical protein	-
I6L37_RS09320 (I6L37_09320)	1923909..1926356	+	2448	WP_216993855.1	type I restriction-modification system subunit M	-
I6L37_RS09325 (I6L37_09325)	1926356..1927618	+	1263	WP_216993856.1	restriction endonuclease subunit S	-
I6L37_RS09330 (I6L37_09330)	1927887..1928540	+	654	WP_216993857.1	DUF4433 domain-containing protein	Toxin
I6L37_RS09335 (I6L37_09335)	1928537..1929601	+	1065	WP_216993858.1	macro domain-containing protein	Antitoxin
I6L37_RS09340 (I6L37_09340)	1929676..1932807	+	3132	WP_216993859.1	HsdR family type I site-specific deoxyribonuclease	-
I6L37_RS09345 (I6L37_09345)	1932807..1933520	+	714	WP_005331303.1	SprT family zinc-dependent metalloprotease	-
I6L37_RS09350 (I6L37_09350)	1933539..1934477	-	939	WP_171269279.1	restriction endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hcp / vgrG1	1901003..1929601	28598

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• ssDNA thymidine ADP-ribosyltransferase, DarT (17-216)

Antitoxin

• Macro domain (18-131)

Sequences

Toxin

Protein

• Length: 218 a.a.
• Molecular weight: 25329.92 Da
• Isoelectric Point: 7.0172

>T207123 WP_216993857.1 NZ_CP077399:1927887-1928540 [Aeromonas sp. FDAARGOS 1407]
MAYDYSQSLNPQKALIFRIVHRDNLEWILTHGLWAGNGQQQNPHWVHIGLPELIAKRARHPVPLAPYGVLNDYVPFYFTP
FSPMLSNIHSGRGVPQRDNDEILILVSSLHRMAELGLPFVFTDSHAYYQWANFYVDLGDLGRIDWPLLQRRDFKRDADDL
SKLERYQAEALIHQHCPIEALLGVVCYNEEIKNRVEQCMNRVGVARPVYVRDGWYFR

Nucleotide

• Length: 654 bp

>T207123 NZ_CP102891:348106-348453 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCTTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGGTTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin

Protein

• Length: 355 a.a.
• Molecular weight: 39674.83 Da
• Isoelectric Point: 6.6468

>AT207123 WP_216993858.1 NZ_CP077399:1928537-1929601 [Aeromonas sp. FDAARGOS 1407]
MIRYTTGNLLDAPVEALVNTVNTVGVMGKGIALMFKERFPANMRAYAEACKQGDVVTGKMFITQTGELLGPRWIVNFPTK
QHWRNPAQMAWIQDGLQDLRAWLQAQQVSSIAIPPLGAGNGGLPWPEVKQAIETALGDLDIDILLYEPSHQYQNVAKRGG
VAELTPARALIAELVRRYWFLGMECSLLEIQKLAWFLARVIGRNPMGDPLQLQFKAHRYGPYANNLTHLLNAMDGSYLQS
DKRIPDSKPFDVIWFNEAKKQELAVYLNTEAKAFLPILEQTTALIDGFESPYGMELLATVDWLMVEEGCAPTLSALREGL
HRWPAGTPWGDRKARLFDDRSLQIALTRLQQGLV

Nucleotide

• Length: 1065 bp

>AT207123 NZ_CP102891:348453-348752 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCAGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA