Detailed information of TA system TA207122

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 3814358..3815011
• Replicon: chromosome
• Accession: NZ_CP077398
• Organism: Acinetobacter nosocomialis strain FDAARGOS 1395

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: I6L25_RS17925
• Protein ID: WP_025469375.1
• Coordinates: 3814622..3815011 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: N8SCE2
• Locus tag: I6L25_RS17920
• Protein ID: WP_002049719.1
• Coordinates: 3814358..3814615 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6L25_RS17900 (I6L25_17900)	3809873..3810880	+	1008	WP_002049752.1	DNA-directed RNA polymerase subunit alpha	-
I6L25_RS17905 (I6L25_17905)	3810899..3811276	+	378	WP_002049717.1	50S ribosomal protein L17	-
I6L25_RS17910 (I6L25_17910)	3811457..3812947	+	1491	WP_004711820.1	NAD(P)/FAD-dependent oxidoreductase	-
I6L25_RS17915 (I6L25_17915)	3812996..3814168	-	1173	WP_002049748.1	acyl-CoA dehydrogenase family protein	-
I6L25_RS17920 (I6L25_17920)	3814358..3814615	+	258	WP_002049719.1	succinate dehydrogenase assembly factor 2	Antitoxin
I6L25_RS17925 (I6L25_17925)	3814622..3815011	+	390	WP_025469375.1	hypothetical protein	Toxin
I6L25_RS17930 (I6L25_17930)	3815779..3816864	+	1086	WP_002049690.1	hypothetical protein	-
I6L25_RS17935 (I6L25_17935)	3816948..3817514	+	567	WP_004711824.1	rhombosortase	-
I6L25_RS17940 (I6L25_17940)	3817702..3819897	+	2196	WP_004711827.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15626.68 Da
• Isoelectric Point: 10.2614

>T207122 WP_025469375.1 NZ_CP077398:3814622-3815011 [Acinetobacter nosocomialis]
MTNHLNFKLKYSRFAIIFQFFIGLSLAVLFYQLLPILWWLVTVSLLFISFIFFLKRPQLAQIAHLDQKLWSLSFHSEQTI
SRVEILKIIDYQIFIVVYFEGRKTLTSVIWFDQMPLSHWKQLKTLEKFY

Nucleotide

• Length: 390 bp

>T207122 NZ_CP102891:322136-322504 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTATTAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGCGGATGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10278.71 Da
• Isoelectric Point: 4.7620

>AT207122 WP_002049719.1 NZ_CP077398:3814358-3814615 [Acinetobacter nosocomialis]
MSEEMTLEERKVVYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIHKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT207122 NZ_CP102891:321918-322139 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0Q1QI86