Detailed information of TA system TA207121

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 3850899..3852463
• Replicon: chromosome
• Accession: NZ_CP077395
• Organism: Aeromonas sp. FDAARGOS 1409

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: I6L39_RS17955
• Protein ID: WP_216990418.1
• Coordinates: 3851153..3852463 (+)
• Length: 437 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: I6L39_RS17950
• Protein ID: WP_216990417.1
• Coordinates: 3850899..3851153 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6L39_RS20305	3850292..3850743	+	452	Protein_3421	transposase	-
I6L39_RS17950 (I6L39_17950)	3850899..3851153	+	255	WP_216990417.1	helix-turn-helix domain-containing protein	Antitoxin
I6L39_RS17955 (I6L39_17955)	3851153..3852463	+	1311	WP_216990418.1	type II toxin-antitoxin system HipA family toxin	Toxin
I6L39_RS17965 (I6L39_17965)	3853498..3855669	+	2172	WP_216990419.1	catalase/peroxidase HPI	-
I6L39_RS17970 (I6L39_17970)	3855895..3856464	-	570	WP_216990420.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 437 a.a.
• Molecular weight: 49089.31 Da
• Isoelectric Point: 7.4269

>T207121 WP_216990418.1 NZ_CP077395:3851153-3852463 [Aeromonas sp. FDAARGOS 1409]
MASLTVYMNGYRVGTFTKATNGAHQFQYDESWVKLPGSRPISLSMPLRQQRYQGDEAYNFFDNLLPDNPEVRNRVVARYQ
ADSTQPFDLLSCIGQDSVGALQLVAQGRPVPDVKRIECKPLSDAELEQILTSYQQGIPLGMVREEDDFRISIAGAQEKTA
LLYLDNRWCLPHAATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKALGLPVPHCFIMQVGKVKALAVERFDRR
YATDRSWIMRLPQEDFCQVLNVPSARKYESHGGPGIADIMTTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSMYPAFGGKGLHPRDAKLAMGLAATKGKKYAIEQIFPRHFYQTAKAIGFEQAQMEKIIRELTDNL
DEVISIVRQQLPDTFPTEIADSILGGLSSKAQRLKR

Nucleotide

• Length: 1311 bp

>T207121 NZ_CP102889:c5195404-5195021 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
AGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9329.70 Da
• Isoelectric Point: 7.9851

>AT207121 WP_216990417.1 NZ_CP077395:3850899-3851153 [Aeromonas sp. FDAARGOS 1409]
MKVTSAKQLSACLKDARLSQKLSQGKVADKVGIRQDTVSSFELNPESTKLETLFKILAALELSLDIRPRTDPAENTAPGW
KEEW

Nucleotide

• Length: 255 bp

>AT207121 NZ_CP102889:c5195646-5195404 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA