Detailed information of TA system TA207120

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 4134699..4136272
• Replicon: chromosome
• Accession: NZ_CP077394
• Organism: Aeromonas sp. FDAARGOS 1408

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A2I8R9Y0
• Locus tag: I6L38_RS19155
• Protein ID: WP_047437768.1
• Coordinates: 4134699..4136018 (-)
• Length: 440 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: I6L38_RS19160
• Protein ID: WP_017410478.1
• Coordinates: 4136018..4136272 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6L38_RS19140 (I6L38_19140)	4130591..4131355	+	765	WP_017783539.1	ATP-binding cassette domain-containing protein	-
I6L38_RS19145 (I6L38_19145)	4131374..4132297	+	924	WP_043171126.1	ABC transporter substrate-binding protein	-
I6L38_RS19150 (I6L38_19150)	4132297..4134279	+	1983	WP_043171127.1	Fe(3+)-hydroxamate ABC transporter permease FhuB	-
I6L38_RS19155 (I6L38_19155)	4134699..4136018	-	1320	WP_047437768.1	type II toxin-antitoxin system HipA family toxin	Toxin
I6L38_RS19160 (I6L38_19160)	4136018..4136272	-	255	WP_017410478.1	helix-turn-helix domain-containing protein	Antitoxin
I6L38_RS19165 (I6L38_19165)	4136968..4137981	-	1014	WP_000845039.1	class 1 integron integrase IntI1	-
I6L38_RS19170 (I6L38_19170)	4138126..4138623	+	498	WP_001083725.1	trimethoprim-resistant dihydrofolate reductase DfrA12	-
I6L38_RS19175 (I6L38_19175)	4138735..4139025	+	291	WP_001336345.1	DUF1010 domain-containing protein	-
I6L38_RS19180 (I6L38_19180)	4139031..4139869	+	839	Protein_3702	AadA family aminoglycoside 3''-O-nucleotidyltransferase	-
I6L38_RS19185 (I6L38_19185)	4139986..4140333	+	348	WP_000679427.1	quaternary ammonium compound efflux SMR transporter QacE delta 1	-
I6L38_RS19190 (I6L38_19190)	4140327..4141166	+	840	WP_000259031.1	sulfonamide-resistant dihydropteroate synthase Sul1	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 440 a.a.
• Molecular weight: 49536.51 Da
• Isoelectric Point: 6.8810

>T207120 WP_047437768.1 NZ_CP077394:c4136018-4134699 [Aeromonas sp. FDAARGOS 1408]
MANLAVYMNGYRVGTFTKTTSGAHHFQYHESWLAQPGSRPISLSMPLRHQTYRGDEAYNFFDNLLPDNTEVRNRVVARYQ
AASTQPFDLLSCIGQDSVGALQLVTEGHDVPDVRRIDYKALSDDELEQILTSYKSGIPLGMVREQEEFRISIAGAQEKTA
LLYLDGRWYLPLNATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKEFGLPVPHCFMMQVGQVKALAVERFDRR
YAADRSWIMRLPQEDFCQVLNVPSARKYENHGGPGITDIMKTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSVYPVFGGRGLNRRDAKLAMGLASSKGKKYAIEQIFPRHFFQTAKAVGFERSAMEEILTELANSV
DDVIERVTQQLPAGFPDTISSTILEGLKARSARLIKGWD

Nucleotide

• Length: 1320 bp

>T207120 NZ_CP102889:c4871775-4870858 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCAATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9293.62 Da
• Isoelectric Point: 7.9834

>AT207120 WP_017410478.1 NZ_CP077394:c4136272-4136018 [Aeromonas sp. FDAARGOS 1408]
MKVTSAKQLSACIKDARLSQKLSQGKVAEKVGIRQDTVSSFELNPESTKLETLFKILAALELSVDIKPRNESSESPASGW
KEEW

Nucleotide

• Length: 255 bp

>AT207120 NZ_CP102889:c4872539-4871781 [Klebsiella pneumoniae]
ATGGCAACAAAATTAAACTGGCTGCTGCAAAACAGCGCTCCCGGAGATGTGATCCTTCAGTCCTGGTTAAGCCAGCATGC
CATCTCTCCCTCTCTGGCCTTTAAATACGCGCAAAGTGGCTGGTTAAAAAAAAGAGGCAACGGCGTATATGCGCGTGCGG
GACGTGAGCCGGAGTGGAACGATGCATTAGCATGTTTGCAAAATCAGCTTGCCGCTCCGGTGTATGTTGCGGGGCTCAGT
AGCTTAGTCTGGCAGGGCCGTTCACACTATCTACAGCTAAAACAAAACCAGTGCTGGCTTAGTGTGGAAAATAAAGCGCT
GCTGCCGAAATGGTTCAGGGAATTCCCGGGTGTGGAGTGGATAGTCATATCGGGGAAAAAACTGCCGGTGCTGGATGATA
GATACCGTGTAACGCTTGATATAAAAGGGAAAAAACTCATCGGCAGTGCGCCAGAACTGGCTGCTTACGAGTTGCTGAGC
GCGGTGCCGGGGACCCTCTCATTTAACCACGCTGCAGAGCTTTTCCAGGGGCTGGTTAATCTTAATCCTCGTAAAGTAGA
GTATCTTCTTTCCGTCAGCCAGTCCGTGCAGGCCAAGCGTTTGTATCTCTTCTTCGCCAGTTTTTACGAGCATGGCTGGC
TCAAACGAATCGATAGCCAAAAAATCGATCTGGGAGCGGGCAAGCGGCAAATCGTGGAAAATGGAAAGTTCAATGCTCAA
TACCAAATCACAGTGCCTGAACGCTTTCAAAAGGAATAA

Structures

Toxin

• AlphaFold DB: A0A2I8R9Y0