Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2087150..2087778 Replicon chromosome
Accession NC_003869
Organism Thermoanaerobacter tengcongensis MB4 (Caldanaerobacter subterraneus)

Toxin (Protein)


Gene name mazF Uniprot ID A0A0F5PMK0
Locus tag TTE_RS10330 Protein ID WP_031314082.1
Coordinates 2087150..2087500 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID U5CGD4
Locus tag TTE_RS10335 Protein ID WP_011026253.1
Coordinates 2087503..2087778 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TTE_RS10310 2082630..2083128 - 499 Protein_2036 IS607 family transposase -
TTE_RS10315 2083208..2083942 - 735 WP_011026250.1 WecB/TagA/CpsF family glycosyltransferase -
TTE_RS10320 2083955..2085034 - 1080 WP_009610643.1 polysaccharide pyruvyl transferase CsaB -
TTE_RS10325 2085036..2087048 - 2013 WP_011026251.1 hypothetical protein -
TTE_RS10330 2087150..2087500 - 351 WP_031314082.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
TTE_RS10335 2087503..2087778 - 276 WP_011026253.1 ribbon-helix-helix protein, CopG family Antitoxin
TTE_RS10340 2087867..2089033 - 1167 WP_011026254.1 alanine racemase -
TTE_RS10345 2089052..2089684 - 633 WP_011026255.1 hypothetical protein -
TTE_RS10350 2089691..2091229 - 1539 WP_011026256.1 bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase -
TTE_RS10355 2091226..2091609 - 384 WP_011026257.1 holo-ACP synthase -
TTE_RS10360 2091699..2092061 - 363 WP_011026258.1 hypothetical protein -
TTE_RS10365 2092312..2092497 - 186 WP_011026259.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-43)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12913.03 Da        Isoelectric Point: 6.4714

>T20711 WP_031314082.1 NC_003869:c2087500-2087150 [Caldanaerobacter subterraneus subsp. tengcongensis MB4]
MVVKRGDLFYADLSPVIGSEQGGIRPVLIIQNDIGNKYSPTVIVAAITSQINKAKLPTHVEINGAEYGLQKDSVILLEQI
RTIDKKRLREKIGHLDQEMMEKVNEALQISLGLIDF

Download         Length: 351 bp

>T20711 NC_003869:c2087500-2087150 [Caldanaerobacter subterraneus subsp. tengcongensis MB4]
ATGGTAGTGAAAAGAGGAGACTTGTTTTATGCCGATTTAAGCCCTGTGATAGGCTCTGAACAGGGTGGAATTCGGCCTGT
ACTTATAATTCAAAATGATATAGGGAATAAGTATAGTCCCACTGTGATCGTAGCGGCAATAACATCACAGATCAATAAAG
CAAAGCTGCCCACCCATGTAGAGATAAATGGGGCTGAATACGGCCTTCAGAAAGATTCTGTGATTCTTTTGGAACAGATA
AGGACTATTGATAAAAAGCGTTTGAGGGAGAAAATAGGACATCTTGATCAGGAAATGATGGAAAAGGTCAATGAGGCTTT
ACAAATAAGCTTGGGATTGATTGATTTTTAG

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10507.27 Da        Isoelectric Point: 6.3662

>AT20711 WP_011026253.1 NC_003869:c2087778-2087503 [Caldanaerobacter subterraneus subsp. tengcongensis MB4]
VGETKRILVSLPQSLLEEVDVLAAMENRNRSEFIREAMKLYIRERKKAQIRESMKKGYMEMAAINSELAEMGLTAENECF
AGYEMKLKKCD

Download         Length: 276 bp

>AT20711 NC_003869:c2087778-2087503 [Caldanaerobacter subterraneus subsp. tengcongensis MB4]
GTGGGCGAAACAAAGCGGATTCTCGTCAGTTTGCCTCAAAGCCTGCTGGAAGAAGTTGATGTTCTTGCCGCTATGGAAAA
CAGAAATCGCAGTGAGTTTATAAGGGAAGCGATGAAATTGTATATACGTGAGAGGAAAAAAGCGCAGATACGAGAAAGCA
TGAAAAAGGGTTATATGGAGATGGCAGCTATAAATTCTGAACTTGCGGAAATGGGCCTAACCGCAGAAAATGAATGTTTT
GCAGGTTATGAAATGAAACTGAAAAAGTGTGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0F5PMK0

Antitoxin

Source ID Structure
AlphaFold DB U5CGD4

References