Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1764577..1765234 Replicon chromosome
Accession NZ_CP077392
Organism Enterobacter hormaechei strain FDAARGOS 1435

Toxin (Protein)


Gene name cptA Uniprot ID A0A0A6GSQ9
Locus tag I6L65_RS08410 Protein ID WP_022649305.1
Coordinates 1764824..1765234 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag I6L65_RS08405 Protein ID WP_003863437.1
Coordinates 1764577..1764843 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L65_RS08390 (I6L65_08390) 1761124..1761855 - 732 WP_022649308.1 MurR/RpiR family transcriptional regulator -
I6L65_RS08395 (I6L65_08395) 1762122..1762781 + 660 WP_022649307.1 hemolysin III family protein -
I6L65_RS08400 (I6L65_08400) 1763302..1764282 - 981 WP_048965618.1 tRNA-modifying protein YgfZ -
I6L65_RS08405 (I6L65_08405) 1764577..1764843 + 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
I6L65_RS08410 (I6L65_08410) 1764824..1765234 + 411 WP_022649305.1 protein YgfX Toxin
I6L65_RS08415 (I6L65_08415) 1765236..1765757 - 522 WP_023306886.1 flavodoxin FldB -
I6L65_RS08420 (I6L65_08420) 1765859..1766755 + 897 WP_048965619.1 site-specific tyrosine recombinase XerD -
I6L65_RS08425 (I6L65_08425) 1766784..1767497 + 714 WP_022649304.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I6L65_RS08430 (I6L65_08430) 1767503..1769236 + 1734 WP_048965620.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T207107 WP_022649305.1 NZ_CP077392:1764824-1765234 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T207107 NZ_CP102884:46685-46972 [Klebsiella pneumoniae]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT207107 WP_003863437.1 NZ_CP077392:1764577-1764843 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT207107 NZ_CP102884:46446-46685 [Klebsiella pneumoniae]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6GSQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References