Detailed information of TA system TA207106

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 1677322..1678103
• Replicon: chromosome
• Accession: NZ_CP077392
• Organism: Enterobacter hormaechei strain FDAARGOS 1435

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: -
• Locus tag: I6L65_RS07965
• Protein ID: WP_048966570.1
• Coordinates: 1677612..1678103 (+)
• Length: 164 a.a.

Antitoxin (Protein)

• Gene name: TacA2
• Uniprot ID: A0A3S0FY21
• Locus tag: I6L65_RS07960
• Protein ID: WP_022649379.1
• Coordinates: 1677322..1677615 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6L65_RS07945 (I6L65_07945)	1674308..1674622	-	315	WP_003862457.1	lipoprotein	-
I6L65_RS07950 (I6L65_07950)	1674798..1675430	+	633	WP_003862456.1	response regulator transcription factor	-
I6L65_RS07955 (I6L65_07955)	1675427..1677220	+	1794	WP_063137639.1	hybrid sensor histidine kinase/response regulator	-
I6L65_RS07960 (I6L65_07960)	1677322..1677615	+	294	WP_022649379.1	DUF1778 domain-containing protein	Antitoxin
I6L65_RS07965 (I6L65_07965)	1677612..1678103	+	492	WP_048966570.1	GNAT family N-acetyltransferase	Toxin
I6L65_RS07970 (I6L65_07970)	1678255..1679949	-	1695	WP_048966569.1	hypothetical protein	-
I6L65_RS07975 (I6L65_07975)	1679946..1681856	-	1911	WP_022649376.1	hypothetical protein	-
I6L65_RS07980 (I6L65_07980)	1682371..1682823	+	453	WP_022649375.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1674798..1682823	8025

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (87-144)

Antitoxin

• Vibrio phage ICP1, Orf50 (14-88)

Sequences

Toxin

Protein

• Length: 164 a.a.
• Molecular weight: 17471.40 Da
• Isoelectric Point: 8.1405

>T207106 WP_048966570.1 NZ_CP077392:1677612-1678103 [Enterobacter hormaechei]
MISAPVPLRAGHILTPFCCGVDSMDNWLKQRAMKNQASGASRTFVCCGGDSNVLAYYALASSAVTMNTAPGRFRRNMPDP
IPVVVLGRLAVDQSLHGQGVGRALVRDAGLRVIQVAESIGIRGMLVHALSDEAREFYLRVGFEPSPMDPMILMVTLGDLV
ASI

Nucleotide

• Length: 492 bp

>T207106 NZ_CP102884:36671-37141 [Klebsiella pneumoniae]
GTGATCTTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACCCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATACAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAATTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10959.58 Da
• Isoelectric Point: 8.6351

>AT207106 WP_022649379.1 NZ_CP077392:1677322-1677615 [Enterobacter hormaechei]
MPAANTMAVKRETLNLRIRPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLTRLDQAPAPN
AALRKTMQTLAPWEQEK

Nucleotide

• Length: 294 bp

>AT207106 NZ_CP102884:36231-36674 [Klebsiella pneumoniae]
ATGAAAACTTTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
TGTAGCGCTCCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGTGAACCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCAACCACATTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTTATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAGGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAAACGGGAGCCTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A3S0FY21