Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2917707..2918753 Replicon chromosome
Accession NZ_CP077388
Organism Providencia rettgeri strain FDAARGOS 1451

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag I6L81_RS13210 Protein ID WP_254178399.1
Coordinates 2918016..2918753 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag I6L81_RS13205 Protein ID WP_131680787.1
Coordinates 2917707..2917976 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L81_RS13175 (I6L81_13175) 2912764..2912907 + 144 WP_042846776.1 50S ribosomal protein L34 -
I6L81_RS13180 (I6L81_13180) 2912929..2913288 + 360 WP_072035181.1 ribonuclease P protein component -
I6L81_RS13185 (I6L81_13185) 2913252..2913512 + 261 WP_042846775.1 membrane protein insertion efficiency factor YidD -
I6L81_RS13190 (I6L81_13190) 2913515..2915164 + 1650 WP_042846774.1 membrane protein insertase YidC -
I6L81_RS13195 (I6L81_13195) 2915292..2916656 + 1365 WP_042846829.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
I6L81_RS13200 (I6L81_13200) 2916787..2917551 + 765 WP_042846773.1 hypothetical protein -
I6L81_RS13205 (I6L81_13205) 2917707..2917976 + 270 WP_131680787.1 helix-turn-helix domain-containing protein Antitoxin
I6L81_RS13210 (I6L81_13210) 2918016..2918753 + 738 WP_254178399.1 HipA domain-containing protein Toxin
I6L81_RS13215 (I6L81_13215) 2918725..2919555 - 831 WP_042846771.1 formate dehydrogenase accessory sulfurtransferase FdhD -
I6L81_RS13220 (I6L81_13220) 2919732..2922779 + 3048 WP_282551101.1 formate dehydrogenase-N subunit alpha -
I6L81_RS13225 (I6L81_13225) 2922791..2923735 + 945 WP_004906826.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(4-200)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-65)


Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 27919.08 Da        Isoelectric Point: 7.5113

>T207103 WP_254178399.1 NZ_CP077388:2918016-2918753 [Providencia rettgeri]
VTLFAQVLGLISLNDVPHSFILNVGEIKALAVERFERKYSSDSSWIMRLPQEDFCQTLNISPARKYQNHGGPGISEIMNY
LLGSINAEKDRYQFMKSQVLFWLLAATDGHAKNFSLFIEPEGRYQLTPFYDILSMYPSYGGRGINPRDAKLAMGLKGTRE
MKYNIEQIFPRHFFATAKEVGFDRTEMEKILIEFDEQMESVITKVREQLPTNFPKHIADSILSGLHHKAARLKKVGINPL
PDSDG

Download         Length: 738 bp

>T207103 NZ_CP102883:c4752052-4751768 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGTGAATAAACGGCTCTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10030.23 Da        Isoelectric Point: 10.0521

>AT207103 WP_131680787.1 NZ_CP077388:2917707-2917976 [Providencia rettgeri]
MKVTNTRQLSAYMKDVRETKKLSQSKVASKVGIRQDTVSSFELSPDSTKLETFFKILSALNLELDIKPRNESGSSNSNSN
SNSGWKEEW

Download         Length: 270 bp

>AT207103 NZ_CP102883:c4752284-4752042 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGTGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References