Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2031383..2032029 Replicon chromosome
Accession NZ_CP077388
Organism Providencia rettgeri strain FDAARGOS 1451

Toxin (Protein)


Gene name Hha Uniprot ID A0A1J0E3F0
Locus tag I6L81_RS09415 Protein ID WP_042846891.1
Coordinates 2031826..2032029 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A1J0E3I4
Locus tag I6L81_RS09410 Protein ID WP_042846890.1
Coordinates 2031383..2031751 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L81_RS09385 (I6L81_09385) 2026598..2027359 - 762 WP_042846885.1 DNA polymerase III subunit epsilon -
I6L81_RS09390 (I6L81_09390) 2027414..2027884 + 471 WP_042846886.1 ribonuclease HI -
I6L81_RS09395 (I6L81_09395) 2027881..2028615 - 735 WP_042846887.1 methyltransferase domain-containing protein -
I6L81_RS09400 (I6L81_09400) 2028649..2029401 + 753 WP_042846888.1 hydroxyacylglutathione hydrolase -
I6L81_RS09405 (I6L81_09405) 2029483..2030853 + 1371 WP_048608373.1 murein transglycosylase D -
I6L81_RS09410 (I6L81_09410) 2031383..2031751 + 369 WP_042846890.1 Hha toxicity modulator TomB Antitoxin
I6L81_RS09415 (I6L81_09415) 2031826..2032029 + 204 WP_042846891.1 HHA domain-containing protein Toxin
I6L81_RS09425 (I6L81_09425) 2032613..2033071 - 459 WP_042846892.1 YbaY family lipoprotein -
I6L81_RS09430 (I6L81_09430) 2033311..2034177 + 867 WP_042846893.1 acyl-CoA thioesterase II -
I6L81_RS09435 (I6L81_09435) 2034318..2035601 - 1284 WP_217008449.1 ammonium transporter AmtB -
I6L81_RS09440 (I6L81_09440) 2035612..2035950 - 339 WP_042846895.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8087.38 Da        Isoelectric Point: 6.9770

>T207102 WP_042846891.1 NZ_CP077388:2031826-2032029 [Providencia rettgeri]
MTKSDYLMRLRKCTTIETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPPSVWKFVR

Download         Length: 204 bp

>T207102 NZ_CP102883:c4666296-4665955 [Klebsiella pneumoniae]
ATGAATACTTTACCTGTAATAAACCAGCGGGCTATTCAGTTATGCCCATCGCCTGTAACTATCTGGCAAACGTTGCTAAC
TCGTTTACTGGAACAACACTACGGGCTGGCGCTGAACGACACACCGTTCGGTGATGAAAGCGTGATTCAGGAACATATCG
AGGCCGGTATTACACTCGTTGATGCCGTTAACTTCTTGGTGGAAAAGTACGAGCTGGTTCGTATCGACCGCTGGGCGTTT
GGCTGGTTGGAACCATCTCCATACTTGCGAGCTGAAGACATTCTGCGAATGCGTCGGGACATGGGGCTGTTGCGAGGCTG
CAACCACACTGCAGCAATGTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14123.05 Da        Isoelectric Point: 4.3849

>AT207102 WP_042846890.1 NZ_CP077388:2031383-2031751 [Providencia rettgeri]
MDEYSPKRHDIAELKYLCNSLNRDAILSLQKTNTHWINDLSSAQSAALNELIEHIAAFVWRFKIKYPKENLVISLIEEYL
DETYDLFGSPVITLSEIIDWETMNQNLVSVLDDDLKCLTSKT

Download         Length: 369 bp

>AT207102 NZ_CP102883:c4666681-4666331 [Klebsiella pneumoniae]
ATGTCGAATAAGACACAGACAGTGAATGGTGATACTGCCGAGCCCAGGTGGGGCTTGAGTTGTAACGTCATCCCTTGTTT
TGGTGCACGTCTGGTCCAGGAAGGTAACCGCCTACATTATCTGGCTGACCGCGCCAGCATAACAGGTCAGTTCAATGAAG
CGGATTTAATCCATCCTGACCAGGCATTCCCGGTCCTGTTGAAGCAGGCAGAGCTCATGCTTACCAGCGGCGAACTGAAT
CCCCGACACCAGCATTGCGTCACGTTCTGTGAAAAGGGGTTGACCTGCGAAGCTGATACGCTGGGTTCCTGTGGCCACGT
CTATATTGTCATTTACCCTACTCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J0E3F0

Antitoxin

Source ID Structure
AlphaFold DB A0A1J0E3I4

References