Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1423001..1423658 Replicon chromosome
Accession NZ_CP077388
Organism Providencia rettgeri strain FDAARGOS 1451

Toxin (Protein)


Gene name cptA Uniprot ID A0A1J0E9L4
Locus tag I6L81_RS06775 Protein ID WP_042845040.1
Coordinates 1423001..1423411 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A1J0E9J6
Locus tag I6L81_RS06780 Protein ID WP_042845042.1
Coordinates 1423392..1423658 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L81_RS06755 (I6L81_06755) 1418940..1420673 - 1734 WP_129466205.1 single-stranded-DNA-specific exonuclease RecJ -
I6L81_RS06760 (I6L81_06760) 1420683..1421387 - 705 WP_042845413.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I6L81_RS06765 (I6L81_06765) 1421409..1422311 - 903 WP_129466206.1 site-specific tyrosine recombinase XerD -
I6L81_RS06770 (I6L81_06770) 1422429..1422947 + 519 WP_042845038.1 flavodoxin FldB -
I6L81_RS06775 (I6L81_06775) 1423001..1423411 - 411 WP_042845040.1 protein YgfX Toxin
I6L81_RS06780 (I6L81_06780) 1423392..1423658 - 267 WP_042845042.1 FAD assembly factor SdhE Antitoxin
I6L81_RS06785 (I6L81_06785) 1423908..1424897 + 990 WP_129466207.1 tRNA-modifying protein YgfZ -
I6L81_RS06790 (I6L81_06790) 1424909..1425529 + 621 WP_071548274.1 HD domain-containing protein -
I6L81_RS06795 (I6L81_06795) 1425690..1426580 + 891 WP_254178460.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15461.25 Da        Isoelectric Point: 10.6538

>T207101 WP_042845040.1 NZ_CP077388:c1423411-1423001 [Providencia rettgeri]
VVLWKSNLSISWKTQFFSTCVHGAVGMFLLVAPWAPAHSMIWLPLLAVVVASWAKSQKNISKIKGVAVLVNGNKVQWKKN
EWNIVKAPWLSRYGILLSLEALQGKQQKIHLWVAKDSVSEESWRNLNQLLLQYPDI

Download         Length: 411 bp

>T207101 NZ_CP102883:c4627583-4627050 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATAAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10619.16 Da        Isoelectric Point: 4.8780

>AT207101 WP_042845042.1 NZ_CP077388:c1423658-1423392 [Providencia rettgeri]
MDIENKARIHWACRRGMRELDISIMPFFEYEYDSLTTNDKQVFVRLLECADPDLFNWLMNHGRPDDDELFRMVKLIQEKN
KNRGPVEI

Download         Length: 267 bp

>AT207101 NZ_CP102883:c4627860-4627594 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J0E9L4

Antitoxin

Source ID Structure
AlphaFold DB A0A1J0E9J6

References