Detailed information of TA system TA207100

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 534762..535681
• Replicon: chromosome
• Accession: NZ_CP077388
• Organism: Providencia rettgeri strain FDAARGOS 1451

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A1J0E7D4
• Locus tag: I6L81_RS02610
• Protein ID: WP_042843809.1
• Coordinates: 534762..535223 (-)
• Length: 154 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: I6L81_RS02615
• Protein ID: WP_048607179.1
• Coordinates: 535220..535681 (-)
• Length: 154 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6L81_RS02585 (I6L81_02585)	530264..531724	+	1461	WP_042844339.1	AMP nucleosidase	-
I6L81_RS02590 (I6L81_02590)	531741..532274	+	534	WP_226619150.1	GNAT family N-acetyltransferase	-
I6L81_RS02595 (I6L81_02595)	532331..532753	+	423	WP_042843814.1	helix-turn-helix domain-containing protein	-
I6L81_RS02600 (I6L81_02600)	532860..533819	+	960	WP_181469296.1	acetyl-CoA carboxylase carboxyl transferase subunit alpha	-
I6L81_RS02605 (I6L81_02605)	533863..534753	+	891	WP_042843811.1	LysR family transcriptional regulator	-
I6L81_RS02610 (I6L81_02610)	534762..535223	-	462	WP_042843809.1	RES domain-containing protein	Toxin
I6L81_RS02615 (I6L81_02615)	535220..535681	-	462	WP_048607179.1	DUF2384 domain-containing protein	Antitoxin
I6L81_RS02620 (I6L81_02620)	535771..536238	-	468	WP_042843807.1	DUF1456 family protein	-
I6L81_RS02625 (I6L81_02625)	536424..536738	-	315	WP_042843806.1	AzlD domain-containing protein	-
I6L81_RS02630 (I6L81_02630)	536735..537436	-	702	WP_048607181.1	AzlC family ABC transporter permease	-
I6L81_RS02635 (I6L81_02635)	538123..538764	+	642	WP_048607183.1	leucine efflux protein LeuE	-
I6L81_RS02640 (I6L81_02640)	538824..539282	-	459	WP_042843802.1	GNAT family N-acetyltransferase	-
I6L81_RS02645 (I6L81_02645)	539701..540087	+	387	WP_048607185.1	cytidine deaminase	-
I6L81_RS02650 (I6L81_02650)	540111..540575	+	465	WP_217008297.1	NUDIX domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-148)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (38-95)

Sequences

Toxin

Protein

• Length: 154 a.a.
• Molecular weight: 17499.99 Da
• Isoelectric Point: 6.4846

>T207100 WP_042843809.1 NZ_CP077388:c535223-534762 [Providencia rettgeri]
MILYRLIKSDFAHDAWSGQGARLYGGRWNHKGTPAIYTSTSISLAALEILVHINQDTVLNHFTLLSIEINDRYVMKLSVE
HLPDDWQRDPAPTSTMDIGTTWLTNQDSLALIVPSCIIPYEYNAIINPMHPQFQKVTQTIKPLDFAFDPRFNR

Nucleotide

• Length: 462 bp

>T207100 NZ_CP102883:4025641-4025859 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 154 a.a.
• Molecular weight: 17056.55 Da
• Isoelectric Point: 9.9812

>AT207100 WP_048607179.1 NZ_CP077388:c535681-535220 [Providencia rettgeri]
MRNYIPALPTQPATPPFKPLWRFAGLPAERGIELTHFLRQGLSVTVLDNIQEWSGISKSELLRISGINERNVARRRNAGQ
PLNADESERIARLVRVFDAAVRLFNGDKSMASDWLNHPVKGLGHTRPIELIATESGALEVIDLIGRIEHGVFS

Nucleotide

• Length: 462 bp

>AT207100 NZ_CP102883:4025240-4025614 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Structures

Toxin

• AlphaFold DB: A0A1J0E7D4