Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 21498..22006 Replicon chromosome
Accession NZ_CP077388
Organism Providencia rettgeri strain FDAARGOS 1451

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag I6L81_RS00110 Protein ID WP_166686864.1
Coordinates 21498..21806 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag I6L81_RS00115 Protein ID WP_238563506.1
Coordinates 21806..22006 (-) Length 67 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L81_RS00080 (I6L81_00080) 17390..18226 + 837 WP_042844279.1 CheR family methyltransferase -
I6L81_RS00085 (I6L81_00085) 18226..19293 + 1068 WP_042844278.1 chemotaxis response regulator protein-glutamate methylesterase -
I6L81_RS00090 (I6L81_00090) 19333..19725 + 393 WP_034782834.1 chemotaxis response regulator CheY -
I6L81_RS00095 (I6L81_00095) 19750..20388 + 639 WP_042844277.1 protein phosphatase CheZ -
I6L81_RS00100 (I6L81_00100) 20605..20904 + 300 WP_042844276.1 helix-turn-helix transcriptional regulator -
I6L81_RS00105 (I6L81_00105) 20925..21482 - 558 WP_129465770.1 hypothetical protein -
I6L81_RS00110 (I6L81_00110) 21498..21806 - 309 WP_166686864.1 CcdB family protein Toxin
I6L81_RS00115 (I6L81_00115) 21806..22006 - 201 WP_238563506.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
I6L81_RS00120 (I6L81_00120) 22211..23362 + 1152 WP_048606786.1 flagellar biosynthesis protein FlhB -
I6L81_RS00125 (I6L81_00125) 23355..25454 + 2100 WP_042844272.1 flagellar biosynthesis protein FlhA -
I6L81_RS00130 (I6L81_00130) 25825..26265 - 441 WP_042844271.1 flagellar export chaperone FlgN -
I6L81_RS00135 (I6L81_00135) 26275..26577 - 303 WP_042844270.1 flagellar biosynthesis anti-sigma factor FlgM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(1-66)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11648.70 Da        Isoelectric Point: 6.8393

>T207099 WP_166686864.1 NZ_CP077388:c21806-21498 [Providencia rettgeri]
MQYCLYQNRENTVKHPYLLDIQSNIIDILNTLLVIPLFDSRLAKKPLPTCLNPQLFSNGQVFVLMTHQMACVPHSLLGKE
IVDLNCQQNTIKHAIDLLIDGF

Download         Length: 309 bp

>T207099 NZ_CP102883:c2642308-2640986 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCGCCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCACTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCGCCACTCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 67 a.a.        Molecular weight: 7596.66 Da        Isoelectric Point: 7.7889

>AT207099 WP_238563506.1 NZ_CP077388:c22006-21806 [Providencia rettgeri]
ITVAPELCEQARRAKLNLSAILTCALQAELKRLEAQKWKNENIEGFNQLNRNNEEYGLLSDKYKGF

Download         Length: 201 bp

>AT207099 NZ_CP102883:c2642574-2642308 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGACGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References