Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 55301..56865 Replicon chromosome
Accession NZ_CP077378
Organism Aeromonas sp. FDAARGOS 1406

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag I6L36_RS00310 Protein ID WP_201964151.1
Coordinates 55301..56611 (-) Length 437 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag I6L36_RS00315 Protein ID WP_005329233.1
Coordinates 56611..56865 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L36_RS00290 (I6L36_00290) 50645..51262 + 618 WP_201896614.1 HAD hydrolase family protein -
I6L36_RS00295 (I6L36_00295) 51306..52070 + 765 WP_109112551.1 DeoR/GlpR family DNA-binding transcription regulator -
I6L36_RS00300 (I6L36_00300) 52171..54345 - 2175 WP_216986919.1 catalase/peroxidase HPI -
I6L36_RS00310 (I6L36_00310) 55301..56611 - 1311 WP_201964151.1 type II toxin-antitoxin system HipA family toxin Toxin
I6L36_RS00315 (I6L36_00315) 56611..56865 - 255 WP_005329233.1 helix-turn-helix domain-containing protein Antitoxin
I6L36_RS00320 (I6L36_00320) 57367..57615 + 249 WP_167826046.1 hypothetical protein -
I6L36_RS00325 (I6L36_00325) 58036..58287 - 252 WP_010674977.1 plasmid stabilization protein -
I6L36_RS00330 (I6L36_00330) 58366..59673 - 1308 WP_254052375.1 Fic family protein -
I6L36_RS00335 (I6L36_00335) 59928..60380 + 453 WP_119197630.1 DUF2384 domain-containing protein -
I6L36_RS00340 (I6L36_00340) 60712..61290 + 579 WP_024941319.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 437 a.a.        Molecular weight: 49136.32 Da        Isoelectric Point: 7.1717

>T207098 WP_201964151.1 NZ_CP077378:c56611-55301 [Aeromonas sp. FDAARGOS 1406]
MASLTVYMNGYRVGTFTKATNGAHQFQYDESWVKLPGSRPISLSMPLRQQRYQGDEAYNFFDNLLPDNPEVRNRVVARYQ
ADSTQPFDLLSCIGQDSVGALQLVAQGRPVPDVKRIECKPLSDAELEQILTSYQQGIPLGMVREEDDFRISIAGAQEKTA
LLYLDNRWCLPHAATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKALGLPVPHCFIMQVGKVKALAVERFDRR
YATDRSWIMRLPQEDFCQVLNVPSARKYESHGGPGIADIMTTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSMYPAFGGKGLHPRDAKLAMGLTATKGKKYAIEQIFPRHFYQTAKAIGFEQVQMEKIISELTDNL
DEVISIVRQQLPDTFPTEITDSILGGLSSRAQRLKR

Download         Length: 1311 bp

>T207098 NZ_CP102883:1901688-1901790 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9271.66 Da        Isoelectric Point: 9.1571

>AT207098 WP_005329233.1 NZ_CP077378:c56865-56611 [Aeromonas sp. FDAARGOS 1406]
MKVTSAKQLSACLKDARLSQKLSQGKVAGKVGIRQDTVSSFELNPESTKLETLFKILAALELSLDIRPRTDPAENATPGW
KEEW

Download         Length: 255 bp

>AT207098 NZ_CP102883:c1901797-1901652 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References