Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2978..3600 Replicon plasmid unnamed2
Accession NZ_CP077371
Organism Acinetobacter lwoffii strain FDAARGOS 1394

Toxin (Protein)


Gene name vapC Uniprot ID A0A3D2SM50
Locus tag I6L24_RS15925 Protein ID WP_005020938.1
Coordinates 2978..3373 (-) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID V9M691
Locus tag I6L24_RS15930 Protein ID WP_005020941.1
Coordinates 3370..3600 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L24_RS15910 (I6L24_15915) 1238..1624 + 387 WP_026444417.1 hypothetical protein -
I6L24_RS15915 (I6L24_15920) 1635..1859 + 225 WP_026444418.1 hypothetical protein -
I6L24_RS15920 (I6L24_15925) 2026..2901 - 876 WP_216986662.1 hypothetical protein -
I6L24_RS15925 (I6L24_15930) 2978..3373 - 396 WP_005020938.1 type II toxin-antitoxin system VapC family toxin Toxin
I6L24_RS15930 (I6L24_15935) 3370..3600 - 231 WP_005020941.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
I6L24_RS15935 (I6L24_15940) 4740..5129 + 390 WP_034171729.1 tautomerase family protein -
I6L24_RS15940 (I6L24_15945) 5314..5925 + 612 WP_004889724.1 recombinase family protein -
I6L24_RS15945 (I6L24_15950) 6834..7793 + 960 WP_005130393.1 GlxA family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..47918 47918


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

SpoVT-AbrB domain

(7-37)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14945.32 Da        Isoelectric Point: 6.4818

>T207094 WP_005020938.1 NZ_CP077371:c3373-2978 [Acinetobacter lwoffii]
MIYLLDTNICIYVINHKPEHVFERFKQYQLGQLAISSITASELAFGVEKSGSERNKQALNKFLSPLDILPYDEKAIWHYA
KLRQDLQSTGKIIGSLDMLIAAHALALDVVLVTNNIKEFERIDGLKLENWV

Download         Length: 396 bp

>T207094 NZ_CP102883:325994-326362 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8688.99 Da        Isoelectric Point: 5.0959

>AT207094 WP_005020941.1 NZ_CP077371:c3600-3370 [Acinetobacter lwoffii]
MEVAKVFQTGRSQAVRLPKAFRFNGTEVAIKSFGRGVLLMPIDNPWDVMLEALNEFEVGFKLERADQGEQVREDFK

Download         Length: 231 bp

>AT207094 NZ_CP102883:325776-325997 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGCTCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3D2SM50

Antitoxin

Source ID Structure
AlphaFold DB A0A3D2SM97

References