Detailed information of TA system TA207091

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 357521..358157
• Replicon: chromosome
• Accession: NZ_CP077369
• Organism: Acinetobacter lwoffii strain FDAARGOS 1394

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: I6L24_RS01690
• Protein ID: WP_216986329.1
• Coordinates: 357521..357907 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: N9NUN9
• Locus tag: I6L24_RS01695
• Protein ID: WP_004281484.1
• Coordinates: 357900..358157 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6L24_RS01675 (I6L24_01675)	352825..355107	-	2283	WP_216986328.1	TRAP transporter large permease subunit	-
I6L24_RS01680 (I6L24_01680)	355305..355877	-	573	WP_004281478.1	rhombosortase	-
I6L24_RS01685 (I6L24_01685)	355945..356985	-	1041	WP_004732263.1	hypothetical protein	-
I6L24_RS01690 (I6L24_01690)	357521..357907	-	387	WP_216986329.1	hypothetical protein	Toxin
I6L24_RS01695 (I6L24_01695)	357900..358157	-	258	WP_004281484.1	succinate dehydrogenase assembly factor 2	Antitoxin
I6L24_RS01700 (I6L24_01700)	358341..359513	+	1173	WP_216986330.1	acyl-CoA dehydrogenase family protein	-
I6L24_RS01705 (I6L24_01705)	359574..361064	-	1491	WP_216986331.1	NAD(P)/FAD-dependent oxidoreductase	-
I6L24_RS01710 (I6L24_01710)	361283..361648	-	366	WP_004281488.1	50S ribosomal protein L17	-
I6L24_RS01715 (I6L24_01715)	361667..362674	-	1008	WP_004281489.1	DNA-directed RNA polymerase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-80)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 15421.60 Da
• Isoelectric Point: 9.8575

>T207091 WP_216986329.1 NZ_CP077369:c357907-357521 [Acinetobacter lwoffii]
MDNRCFKLKRSLCALAFQFFIFALLMYLLYQLLPIALWAVCAVIGLVIYQLFYRKTPQIEQFEYLDGREWLLTTKARPTR
RVCISYVIDHQAYIVVYFQHAKARPLLIWCDQLSFKQWKYLKLLTKLI

Nucleotide

• Length: 387 bp

>T207091 NZ_CP102878:148697-148981 [Klebsiella pneumoniae]
ATGACTTATAAGCTGGCCTTTAATGAATCAGCTCTGAAAGAATGGAAAAAATTGGGCCATACCATTCGGGAACAATTCAA
AAAGAAGCTCGCTGAGCGCCTGTTGAACCCACGGGTGCCCGCATCGCAACTACATGGACGCAAAGACCAATACAAAATAA
AGCTCCGTGGCGCAGGCTACCGACTGGTTTACAGTGTCAACGATGATGTTGTGACGGTCACCGTAATTGGCGTCGGTAAA
CGTGAGAATGATGATATTTACAATTTAACCAAACACAGAAATTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10340.82 Da
• Isoelectric Point: 4.6051

>AT207091 WP_004281484.1 NZ_CP077369:c358157-357900 [Acinetobacter lwoffii]
MTDDISLEERKVIYRARRGLKELDVYFDPYVKNHYLNAEPFEKQMFAELVEQEDPDLLDWFMEVSEPPRPELKDFIKKLK
FYVHG

Nucleotide

• Length: 258 bp

>AT207091 NZ_CP102878:148459-148707 [Klebsiella pneumoniae]
ATGGCATTTCAGGTACTAACCACTACTGCAGCAAGCATCACAGAGCTTAAACGTGATCCTATGGGCACTTTCAATGCAGG
AGAAGGTGCCCCTGTAGCCATACTGAATCGCAACGAACCCGCTTTTTACTGTGTACCGCCTGCTCTGTATGCTCAACTGA
TGGAGCTTCTTGAAGATCAGGAGCTGGGTCGTATTGCTGATGAGCGAATTGGTGAGGCGGTAATCGAGGTCAGTCTAGAT
GACTTATAA

Structures

Antitoxin

• AlphaFold DB: N9NUN9