Detailed information of TA system TA020709

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RelB(antitoxin)
• Location: 1663175..1663787
• Replicon: chromosome
• Accession: NC_003485
• Organism: Streptococcus pyogenes MGAS8232

Toxin (Protein)

• Gene name: parE
• Uniprot ID: Q5X9X8
• Locus tag: SPYM18_RS08610
• Protein ID: WP_011018227.1
• Coordinates: 1663452..1663787 (+)
• Length: 112 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: SPYM18_RS08605
• Protein ID: WP_011018226.1
• Coordinates: 1663175..1663462 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SPYM18_RS08580	1658353..1659336	-	984	WP_002982755.1	tagatose-bisphosphate aldolase	-
SPYM18_RS08585	1659340..1660269	-	930	WP_002982751.1	tagatose-6-phosphate kinase	-
SPYM18_RS08590	1660317..1660832	-	516	WP_002982748.1	galactose-6-phosphate isomerase subunit LacB	-
SPYM18_RS08595	1660867..1661295	-	429	WP_002982747.1	galactose-6-phosphate isomerase subunit LacA	-
SPYM18_RS08600	1661741..1662514	+	774	WP_002982738.1	DeoR/GlpR family DNA-binding transcription regulator	-
SPYM18_RS08605	1663175..1663462	+	288	WP_011018226.1	hypothetical protein	Antitoxin
SPYM18_RS08610	1663452..1663787	+	336	WP_011018227.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SPYM18_RS10395	1663939..1664409	+	471	WP_030127322.1	site-specific integrase	-
SPYM18_RS10400	1664372..1664920	+	549	WP_179854859.1	site-specific integrase	-
SPYM18_RS08620	1665052..1665444	-	393	WP_002982716.1	30S ribosomal protein S9	-
SPYM18_RS08625	1665465..1665911	-	447	WP_011018228.1	50S ribosomal protein L13	-
SPYM18_RS08630	1666129..1666335	-	207	WP_002982695.1	helix-turn-helix transcriptional regulator	-
SPYM18_RS08635	1666332..1667030	-	699	WP_011018229.1	hypothetical protein	-
SPYM18_RS08640	1667166..1668026	-	861	WP_002982687.1	DegV family protein	-
SPYM18_RS08645	1668123..1668641	-	519	WP_002982682.1	NYN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-105)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 112 a.a.
• Molecular weight: 13171.97 Da
• Isoelectric Point: 5.2144

>T20709 WP_011018227.1 NC_003485:1663452-1663787 [Streptococcus pyogenes MGAS8232]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKIIHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Nucleotide

• Length: 336 bp

>T20709 NC_003485:1663452-1663787 [Streptococcus pyogenes MGAS8232]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCATCCATTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10950.56 Da
• Isoelectric Point: 5.2318

>AT20709 WP_011018226.1 NC_003485:1663175-1663462 [Streptococcus pyogenes MGAS8232]
MTTVKKNRSVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Nucleotide

• Length: 288 bp

>AT20709 NC_003485:1663175-1663462 [Streptococcus pyogenes MGAS8232]
ATGACTACAGTAAAAAAAAACAGATCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Structures

Toxin

• AlphaFold DB: A0A7Z2QKE7