Detailed information of TA system TA207088

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 102953..103488
• Replicon: plasmid unnamed1
• Accession: NZ_CP077367
• Organism: Pantoea agglomerans strain FDAARGOS 1447

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A8X8DPA1
• Locus tag: I6L77_RS18955
• Protein ID: WP_010257115.1
• Coordinates: 103201..103488 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A379LU84
• Locus tag: I6L77_RS18950
• Protein ID: WP_022624281.1
• Coordinates: 102953..103204 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6L77_RS18930 (I6L77_18925)	98556..98825	-	270	WP_010257103.1	DUF1471 family periplasmic protein YahO	-
I6L77_RS18935 (I6L77_18930)	99101..100237	-	1137	WP_062759503.1	HlyD family secretion protein	-
I6L77_RS18940 (I6L77_18935)	100239..100565	-	327	WP_033759973.1	DUF3302 domain-containing protein	-
I6L77_RS18945 (I6L77_18940)	101160..102812	+	1653	WP_062759502.1	intermembrane transport protein PqiB	-
I6L77_RS18950 (I6L77_18945)	102953..103204	+	252	WP_022624281.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
I6L77_RS18955 (I6L77_18950)	103201..103488	+	288	WP_010257115.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I6L77_RS18960 (I6L77_18955)	103851..104165	+	315	WP_062759501.1	hypothetical protein	-
I6L77_RS18965 (I6L77_18960)	104162..104635	-	474	Protein_89	DUF4225 domain-containing protein	-
I6L77_RS18970 (I6L77_18965)	104600..105747	+	1148	WP_088234235.1	IS3 family transposase	-
I6L77_RS18980 (I6L77_18975)	106222..107148	+	927	WP_062759676.1	MBL fold metallo-hydrolase	-
I6L77_RS18985 (I6L77_18980)	107744..108346	+	603	WP_062759677.1	DUF2913 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Mobilizable plasmid	-	-	1..180597	180597

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-86)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11173.08 Da
• Isoelectric Point: 10.3856

>T207088 WP_010257115.1 NZ_CP077367:103201-103488 [Pantoea agglomerans]
VSYTVKFREEAFKEWQKLDKSLQQQFAKKLKKCCDNPHIPSARLRGIKDCYKIKLRASGFRLVYQVIDDQLVIAVVAVGK
RERSDVYHLASERMR

Nucleotide

• Length: 288 bp

>T207088 NZ_CP102878:36671-37141 [Klebsiella pneumoniae]
GTGATCTTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACCCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATACAAAGCGCAAACATGGAT
GAATTACCGGGCAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAATTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9081.35 Da
• Isoelectric Point: 3.9507

>AT207088 WP_022624281.1 NZ_CP077367:102953-103204 [Pantoea agglomerans]
MPNIILSDTSASVSELKKNPMATVSAGDGYPVAILNRNQPAFYCVPAELYEQMLDALDDQELVKLVSERSGQRLLDVDLD
ALL

Nucleotide

• Length: 252 bp

>AT207088 NZ_CP102878:36231-36674 [Klebsiella pneumoniae]
ATGAAAACTTTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
TGTAGCGCTCCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGTGAACCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCAACCACATTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTTATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAGGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAAACGGGAGCCTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A379LU84