Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3836282..3836913 Replicon chromosome
Accession NZ_CP077366
Organism Pantoea agglomerans strain FDAARGOS 1447

Toxin (Protein)


Gene name hicA Uniprot ID A0A7X5MR53
Locus tag I6L77_RS17815 Protein ID WP_010253953.1
Coordinates 3836734..3836913 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A379AKM6
Locus tag I6L77_RS17810 Protein ID WP_033756573.1
Coordinates 3836282..3836707 (-) Length 142 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L77_RS17790 (I6L77_17790) 3833002..3833511 - 510 WP_010253965.1 phenolic acid decarboxylase -
I6L77_RS17795 (I6L77_17795) 3833617..3834516 + 900 WP_062759495.1 LysR family transcriptional regulator -
I6L77_RS17800 (I6L77_17800) 3834945..3835874 - 930 WP_033770970.1 Rpn family recombination-promoting nuclease/putative transposase -
I6L77_RS21825 3836111..3836200 - 90 Protein_3457 CRISPR-associated protein Cas1 -
I6L77_RS17810 (I6L77_17810) 3836282..3836707 - 426 WP_033756573.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
I6L77_RS17815 (I6L77_17815) 3836734..3836913 - 180 WP_010253953.1 type II toxin-antitoxin system HicA family toxin Toxin
I6L77_RS17820 (I6L77_17820) 3837096..3838520 - 1425 WP_010253950.1 dihydrolipoyl dehydrogenase -
I6L77_RS17825 (I6L77_17825) 3838681..3840582 - 1902 WP_010671838.1 pyruvate dehydrogenase complex dihydrolipoyllysine-residue acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6467.52 Da        Isoelectric Point: 10.7891

>T207085 WP_010253953.1 NZ_CP077366:c3836913-3836734 [Pantoea agglomerans]
MDSSTLISEMKADGWVLTGINGSHHHFTHPTKPGLVTVPHPKKDLPIGTVKSIRKQARI

Download         Length: 180 bp

>T207085 NZ_CP102877:c4752142-4751858 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGTGAATAAACGGCTCTAA

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15436.62 Da        Isoelectric Point: 4.7754

>AT207085 WP_033756573.1 NZ_CP077366:c3836707-3836282 [Pantoea agglomerans]
MFYPIAIEAGDHEHAYGVIVPDLPGCFSAGDTLDEAIKNAKEAITGHIELCVELGHEIPAVSTIETLATNPEYQGYIWAL
VDVDVIRLLGGSEKINVTLPRSLIDRIDRCVASHPEYKSRSGFLAQVALERITAPINRPQK

Download         Length: 426 bp

>AT207085 NZ_CP102877:c4752374-4752132 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGTGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7X5MR53

Antitoxin

Source ID Structure
AlphaFold DB A0A379AKM6

References