Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3580313..3580930 Replicon chromosome
Accession NZ_CP077366
Organism Pantoea agglomerans strain FDAARGOS 1447

Toxin (Protein)


Gene name Hha Uniprot ID E0LTU7
Locus tag I6L77_RS16600 Protein ID WP_003850458.1
Coordinates 3580715..3580930 (+) Length 72 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID E0LTU8
Locus tag I6L77_RS16595 Protein ID WP_003850455.1
Coordinates 3580313..3580690 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L77_RS16565 (I6L77_16565) 3576620..3576874 + 255 WP_010671219.1 type B 50S ribosomal protein L31 -
I6L77_RS16570 (I6L77_16570) 3576886..3577026 + 141 WP_010255896.1 type B 50S ribosomal protein L36 -
I6L77_RS16575 (I6L77_16575) 3577072..3577950 - 879 WP_033785427.1 metal ABC transporter substrate-binding protein -
I6L77_RS16580 (I6L77_16580) 3577966..3578805 - 840 WP_062758242.1 metal ABC transporter permease -
I6L77_RS16585 (I6L77_16585) 3578802..3579470 - 669 WP_033766689.1 ABC transporter ATP-binding protein -
I6L77_RS16590 (I6L77_16590) 3579812..3580165 + 354 WP_031592173.1 hypothetical protein -
I6L77_RS16595 (I6L77_16595) 3580313..3580690 + 378 WP_003850455.1 Hha toxicity modulator TomB Antitoxin
I6L77_RS16600 (I6L77_16600) 3580715..3580930 + 216 WP_003850458.1 HHA domain-containing protein Toxin
I6L77_RS16610 (I6L77_16610) 3581337..3581648 + 312 WP_033756781.1 MGMT family protein -
I6L77_RS16615 (I6L77_16615) 3581688..3582245 - 558 WP_010255881.1 YbaY family lipoprotein -
I6L77_RS16620 (I6L77_16620) 3582436..3583299 + 864 WP_010255880.1 acyl-CoA thioesterase II -
I6L77_RS16625 (I6L77_16625) 3583349..3584635 - 1287 WP_010255877.1 ammonium transporter AmtB -
I6L77_RS16630 (I6L77_16630) 3584670..3585008 - 339 WP_003850469.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(12-68)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 72 a.a.        Molecular weight: 8510.90 Da        Isoelectric Point: 9.4825

>T207084 WP_003850458.1 NZ_CP077366:3580715-3580930 [Pantoea agglomerans]
MNKTLTKTDYLMRLRRCRSLDTLERVIEKNKYELPEDELAVFYSAADHRLAELTMNKLYDKVPGSVWKFVR

Download         Length: 216 bp

>T207084 NZ_CP102877:c4666386-4666045 [Klebsiella pneumoniae]
ATGAATACTTTACCTGTAATAAACCAGCGGGCTATTCAGTTATGCCCATCGCCTGTAACTATCTGGCAAACGTTGCTAAC
TCGTTTACTGGAACAACACTACGGGCTGGCGCTGAACGACACACCGTTCGGTGATGAAAGCGTGATTCAGGAACATATCG
AGGCCGGTATTACACTCGTTGATGCCGTTAACTTCTTGGTGGAAAAGTACGAGCTGGTTCGTATCGACCGCTGGGCGTTT
GGCTGGTTGGAACCATCTCCATACTTGCGAGCTGAAGACATTCTGCGAATGCGTCGGGACATGGGGCTGTTGCGAGGCTG
CAACCACACTGCAGCAATGTGA

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14636.25 Da        Isoelectric Point: 4.3976

>AT207084 WP_003850455.1 NZ_CP077366:3580313-3580690 [Pantoea agglomerans]
MDEYSPKRHDIAQLKYLCESLFDDSMATLTDSHHGWVNDPTSESNLQLNDLIEHIASFTMNYKIKHVEDEALISQIDEYL
DDTFMLFSNYGVNSPDLQRWQRSAKRLFNLFTEECAFLQQPSHSL

Download         Length: 378 bp

>AT207084 NZ_CP102877:c4666771-4666421 [Klebsiella pneumoniae]
ATGTCGAATAAGACACAGACAGTGAATGGTGATACTGCCGAGCCCAGGTGGGGCTTGAGTTGTAACGTCATCCCTTGTTT
TGGTGCACGTCTGGTCCAGGAAGGTAACCGCCTACATTATCTGGCTGACCGCGCCAGCATAACAGGTCAGTTCAATGAAG
CGGATTTAATCCATCCTGACCAGGCATTCCCGGTCCTGTTGAAGCAGGCAGAGCTCATGCTTACCAGCGGCGAACTGAAT
CCCCGACACCAGCATTGCGTCACGTTCTGTGAAAAGGGGTTGACCTGCGAAGCTGATACGCTGGGTTCCTGTGGCCACGT
CTATATTGTCATTTACCCTACTCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1I5AGC3

Antitoxin

Source ID Structure
AlphaFold DB A0A1I5AG55

References