Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 2784015..2784668 Replicon chromosome
Accession NZ_CP077365
Organism Acinetobacter seifertii strain FDAARGOS 1400

Toxin (Protein)


Gene name cptA Uniprot ID A0A2T5QZ02
Locus tag I6L30_RS13220 Protein ID WP_025469244.1
Coordinates 2784279..2784668 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID N8SCE2
Locus tag I6L30_RS13215 Protein ID WP_002049719.1
Coordinates 2784015..2784272 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L30_RS13195 (I6L30_13195) 2779528..2780535 + 1008 WP_004705386.1 DNA-directed RNA polymerase subunit alpha -
I6L30_RS13200 (I6L30_13200) 2780554..2780931 + 378 WP_002049717.1 50S ribosomal protein L17 -
I6L30_RS13205 (I6L30_13205) 2781113..2782603 + 1491 WP_216984492.1 NAD(P)/FAD-dependent oxidoreductase -
I6L30_RS13210 (I6L30_13210) 2782653..2783825 - 1173 WP_216984493.1 acyl-CoA dehydrogenase family protein -
I6L30_RS13215 (I6L30_13215) 2784015..2784272 + 258 WP_002049719.1 succinate dehydrogenase assembly factor 2 Antitoxin
I6L30_RS13220 (I6L30_13220) 2784279..2784668 + 390 WP_025469244.1 hypothetical protein Toxin
I6L30_RS13225 (I6L30_13225) 2785437..2786522 + 1086 WP_019457778.1 hypothetical protein -
I6L30_RS13230 (I6L30_13230) 2786607..2787173 + 567 WP_004705397.1 rhombosortase -
I6L30_RS13235 (I6L30_13235) 2787361..2789556 + 2196 WP_107972714.1 TRAP transporter large permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15642.79 Da        Isoelectric Point: 9.8344

>T207076 WP_025469244.1 NZ_CP077365:2784279-2784668 [Acinetobacter seifertii]
MINQLNFKLKYSRFSIIFQFFIGLCLAALFYQLIPILWWLVTVCLLFISFIFFLKRPQLVQIAYLDQKLWSLSFHSEQTI
SRVEILKIIDYQIFIVVYFKGDKTLTSVIWFDQMSLSQWKQLKTLEKFY

Download         Length: 390 bp

>T207076 NZ_CP102877:325994-326362 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10278.71 Da        Isoelectric Point: 4.7620

>AT207076 WP_002049719.1 NZ_CP077365:2784015-2784272 [Acinetobacter seifertii]
MSEEMTLEERKVVYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIHKLK
HYVHG

Download         Length: 258 bp

>AT207076 NZ_CP102877:325776-325997 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGCTCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T5QZ02

Antitoxin

Source ID Structure
AlphaFold DB A0A0Q1QI86

References