Detailed information of TA system TA207070

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 1931067..1931703
• Replicon: chromosome
• Accession: NZ_CP077336
• Organism: Acinetobacter lwoffii strain FDAARGOS 1393

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: N8Q3V1
• Locus tag: I6L23_RS09055
• Protein ID: WP_004645066.1
• Coordinates: 1931317..1931703 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: N8Q7K6
• Locus tag: I6L23_RS09050
• Protein ID: WP_004645065.1
• Coordinates: 1931067..1931324 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6L23_RS09030 (I6L23_09030)	1926548..1927555	+	1008	WP_004281489.1	DNA-directed RNA polymerase subunit alpha	-
I6L23_RS09035 (I6L23_09035)	1927574..1927939	+	366	WP_004281488.1	50S ribosomal protein L17	-
I6L23_RS09040 (I6L23_09040)	1928160..1929650	+	1491	WP_004645062.1	NAD(P)/FAD-dependent oxidoreductase	-
I6L23_RS09045 (I6L23_09045)	1929711..1930883	-	1173	WP_004645063.1	acyl-CoA dehydrogenase family protein	-
I6L23_RS09050 (I6L23_09050)	1931067..1931324	+	258	WP_004645065.1	succinate dehydrogenase assembly factor 2	Antitoxin
I6L23_RS09055 (I6L23_09055)	1931317..1931703	+	387	WP_004645066.1	hypothetical protein	Toxin
I6L23_RS09060 (I6L23_09060)	1932239..1933279	+	1041	WP_004645068.1	hypothetical protein	-
I6L23_RS09065 (I6L23_09065)	1933347..1933919	+	573	WP_004281478.1	rhombosortase	-
I6L23_RS09070 (I6L23_09070)	1934117..1936399	+	2283	WP_004645069.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-80)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 15313.44 Da
• Isoelectric Point: 10.1100

>T207070 WP_004645066.1 NZ_CP077336:1931317-1931703 [Acinetobacter lwoffii]
MDNRCFKLKRSLCALAFQLFIFALLMYLLYQLLPIAIWAVCVVIGLVIYQLFYRKTPQIEQFEYLDGREWSLTTKARPTR
RVFISHVIDHQAYIVVYFQHAKARPLLIWCDQLPFKQWKSLKVLTKLV

Nucleotide

• Length: 387 bp

>T207070 NZ_CP102870:69387-69698 [Klebsiella pneumoniae]
ATGCACGTAATTTCAAAAGAGCCTTTTGAGGAAGCGGCAAAGCGATATCCCAACGATTCGTTAGCCATTCGGGCGTTGTA
CCGCTTAGTGCGCGAGACGGACTTCTCTTCTCCAGCTGAGATGCTAACTCTGATACCGAGCCTGGATAATTTTAAGTACA
GGAATAAGTGGTGGGTTTTGGATGTAGGGGGCAACAACTTGAGGGTTATCGCCTATATCAATTTCGTAAATAAGCGCTTC
TACGTGAAGCACATCGCAACCCACGCTGATTACGACAAGTTGACCCGCTATTACAGGGAGAACAAAGAATGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10366.85 Da
• Isoelectric Point: 4.4809

>AT207070 WP_004645065.1 NZ_CP077336:1931067-1931324 [Acinetobacter lwoffii]
MTDDISLEERKVIYRARRGLKELDVYFDPYVKNYYLNAEPFEKQMFAELVEQEDPDLLDWFMEVSEPPRPELKDFIKKLK
FYVHG

Nucleotide

• Length: 258 bp

>AT207070 NZ_CP102870:69695-70114 [Klebsiella pneumoniae]
ATGATTACCGACACTGCAAAAGCCATTGAAGCAACCAAACAACTCGTAGCTGCCGTCCCCTTCCTAGGGGGCAGTTCTTC
CGAGAGCGATTACCGCGAAGCGATGGAGCTGGTGGATTATCTGATCGAGAACGACGACGAGAACCCACTTATTGACTTCC
TGGCGAGTAAGATTGCCGACTATGAAGATAACAGCCCTCGTTTCGCTGAGTTCAACAAAGCTATTGCTGAAATACCAGTC
GGCGTTGCACTTCTGCGAACCCTGATTGACCAGCACAAGCTGTCTTATTCAGACCTTAAGGATGAGATCGGATCTAAATC
ATTGGTCAGCCAAATCCTGTCAGGGCAGCGCTCTTTGACCATCACTCACATAAAAGCTCTTTCCGCGCGCTTCGGTGTAA
AACCTGAGTGGTTCCTATAA

Structures

Toxin

• AlphaFold DB: N8Q3V1

Antitoxin

• AlphaFold DB: N8Q7K6