Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-RHH |
| Location | 24263..24782 | Replicon | plasmid unnamed3 |
| Accession | NZ_CP077334 | ||
| Organism | Lelliottia amnigena strain FDAARGOS 1446 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | A0A837F4A9 |
| Locus tag | I6L76_RS23785 | Protein ID | WP_000277490.1 |
| Coordinates | 24498..24782 (+) | Length | 95 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | A0A6P1V8C3 |
| Locus tag | I6L76_RS23780 | Protein ID | WP_000124732.1 |
| Coordinates | 24263..24505 (+) | Length | 81 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6L76_RS23750 (I6L76_23750) | 19895..20188 | - | 294 | WP_032490874.1 | TrbC/VirB2 family protein | - |
| I6L76_RS23755 (I6L76_23755) | 20198..20866 | - | 669 | WP_032490873.1 | lytic transglycosylase domain-containing protein | - |
| I6L76_RS23760 (I6L76_23760) | 20887..21111 | - | 225 | WP_008815931.1 | hypothetical protein | - |
| I6L76_RS23765 (I6L76_23765) | 21190..21645 | - | 456 | WP_016361119.1 | transcription termination/antitermination NusG family protein | - |
| I6L76_RS23770 (I6L76_23770) | 21904..22266 | + | 363 | WP_008815933.1 | helix-turn-helix transcriptional regulator | - |
| I6L76_RS23775 (I6L76_23775) | 22926..23690 | + | 765 | WP_000076190.1 | plasmid replication initiator RepA | - |
| I6L76_RS23780 (I6L76_23780) | 24263..24505 | + | 243 | WP_000124732.1 | type II toxin-antitoxin system ParD family antitoxin | Antitoxin |
| I6L76_RS23785 (I6L76_23785) | 24498..24782 | + | 285 | WP_000277490.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| I6L76_RS23790 (I6L76_23790) | 25193..25561 | - | 369 | WP_032242306.1 | hypothetical protein | - |
| I6L76_RS23800 (I6L76_23800) | 26979..27569 | + | 591 | WP_014106760.1 | type 3 fimbria major subunit MrkA | - |
| I6L76_RS23805 (I6L76_23805) | 27665..28366 | + | 702 | WP_000820818.1 | type 3 fimbria chaperone MrkB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | mrkA / mrkB / mrkC / mrkD / mrkF | 1..39340 | 39340 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 95 a.a. Molecular weight: 11005.52 Da Isoelectric Point: 6.2103
>T207069 WP_000277490.1 NZ_CP077334:24498-24782 [Lelliottia amnigena]
VYKLTERAADDFAGIYDYTLLKFGEAQADHYTDALEAFFETLAGMPDMGRDYHTVPGVMRIEFQRHAIFYTVRDTDILIA
RILHQQMNHKRHLL
VYKLTERAADDFAGIYDYTLLKFGEAQADHYTDALEAFFETLAGMPDMGRDYHTVPGVMRIEFQRHAIFYTVRDTDILIA
RILHQQMNHKRHLL
Download Length: 285 bp
>T207069 NZ_CP102870:52754-53224 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACAGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGACAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAATTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCCTGGACCGGATATGGTGCGAAAGAGGCTGGTGGGCG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACAGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGACAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAATTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA
Antitoxin
Download Length: 81 a.a. Molecular weight: 8875.01 Da Isoelectric Point: 7.0130
>AT207069 WP_000124732.1 NZ_CP077334:24263-24505 [Lelliottia amnigena]
MARTTSVTIGEQLDSFISRLIDSGRYGSASEVMRSALRLLEQQETNDEVIRQAVIAGLESGESSLSLRDIAAQRKLRHRV
MARTTSVTIGEQLDSFISRLIDSGRYGSASEVMRSALRLLEQQETNDEVIRQAVIAGLESGESSLSLRDIAAQRKLRHRV
Download Length: 243 bp
>AT207069 NZ_CP102870:52314-52757 [Klebsiella pneumoniae]
ATGAAAACTTTTAGTTTGTCCTCAAGTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
TGTAGCGCTCCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGTGAACCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCAACCACATTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTTATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAGGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAAACTGGAGCCTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA
ATGAAAACTTTTAGTTTGTCCTCAAGTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
TGTAGCGCTCCTGGGCCAAATCAATGAAGGCCTGGACGGGAAGGTGGTGAACCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCAACCACATTTAGCCGCAGTGTGAAGGCACGTTTTAACCCGGAACAA
AGTGAACGTCTGGTACGGATTATCCGCGTTATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAGGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAAACTGGAGCCTATGAGG
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A837F4A9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6P1V8C3 |