Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4223217..4223877 Replicon chromosome
Accession NZ_CP077331
Organism Lelliottia amnigena strain FDAARGOS 1446

Toxin (Protein)


Gene name cptA Uniprot ID A0A3S5XTW2
Locus tag I6L76_RS20410 Protein ID WP_059177602.1
Coordinates 4223464..4223877 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A3S5XU93
Locus tag I6L76_RS20405 Protein ID WP_015960306.1
Coordinates 4223217..4223483 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L76_RS20380 (I6L76_20380) 4218458..4219891 - 1434 WP_059177598.1 6-phospho-beta-glucosidase BglA -
I6L76_RS20385 (I6L76_20385) 4220007..4220738 - 732 WP_216981913.1 MurR/RpiR family transcriptional regulator -
I6L76_RS20390 (I6L76_20390) 4220791..4221103 + 313 Protein_3980 N(4)-acetylcytidine aminohydrolase -
I6L76_RS20395 (I6L76_20395) 4221267..4221926 + 660 WP_059177600.1 hemolysin III family protein -
I6L76_RS20400 (I6L76_20400) 4221969..4222949 - 981 WP_216980961.1 tRNA-modifying protein YgfZ -
I6L76_RS20405 (I6L76_20405) 4223217..4223483 + 267 WP_015960306.1 FAD assembly factor SdhE Antitoxin
I6L76_RS20410 (I6L76_20410) 4223464..4223877 + 414 WP_059177602.1 protein YgfX Toxin
I6L76_RS20415 (I6L76_20415) 4223882..4224403 - 522 WP_015960304.1 flavodoxin FldB -
I6L76_RS20420 (I6L76_20420) 4224504..4225400 + 897 WP_059177604.1 site-specific tyrosine recombinase XerD -
I6L76_RS20425 (I6L76_20425) 4225429..4226142 + 714 WP_216980962.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I6L76_RS20430 (I6L76_20430) 4226148..4227881 + 1734 WP_216980963.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16260.13 Da        Isoelectric Point: 11.1910

>T207065 WP_059177602.1 NZ_CP077331:4223464-4223877 [Lelliottia amnigena]
VVLWQSDLRVSWRSQWMSLLLHGMVAAFVLLMPWPLSYTPLWMLLLSLVVFDSVRSQRRINSCQGEIKLLMDSRLRWQGK
EWEIVGTPWMLSFGMMFRLRNVQGGRNQHLWLSADSMDADEWRDLRRMVLQQPTPGR

Download         Length: 414 bp

>T207065 NZ_CP102869:3976497-3976715 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10528.00 Da        Isoelectric Point: 5.1340

>AT207065 WP_015960306.1 NZ_CP077331:4223217-4223483 [Lelliottia amnigena]
MDISNKARIHWACRRGMRELDISVMPFFEYEYDSLSDDDKRLFIRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT207065 NZ_CP102869:3976096-3976470 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTAGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5XTW2

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5XU93

References