Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 3344679..3345295 Replicon chromosome
Accession NZ_CP077331
Organism Lelliottia amnigena strain FDAARGOS 1446

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag I6L76_RS16170 Protein ID WP_202714684.1
Coordinates 3344921..3345295 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag I6L76_RS16165 Protein ID WP_202668693.1
Coordinates 3344679..3344921 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L76_RS16135 (I6L76_16135) 3339725..3340621 + 897 WP_216980761.1 sugar kinase -
I6L76_RS16140 (I6L76_16140) 3340656..3341456 + 801 WP_202694773.1 DeoR/GlpR family DNA-binding transcription regulator -
I6L76_RS16145 (I6L76_16145) 3341589..3342188 + 600 WP_015961052.1 glucose-1-phosphatase -
I6L76_RS16150 (I6L76_16150) 3342182..3343054 + 873 WP_131487116.1 virulence factor BrkB family protein -
I6L76_RS16155 (I6L76_16155) 3343051..3343488 + 438 WP_059180556.1 D-aminoacyl-tRNA deacylase -
I6L76_RS16160 (I6L76_16160) 3343533..3344474 + 942 WP_041689564.1 fatty acid biosynthesis protein FabY -
I6L76_RS16165 (I6L76_16165) 3344679..3344921 + 243 WP_202668693.1 CopG family transcriptional regulator Antitoxin
I6L76_RS16170 (I6L76_16170) 3344921..3345295 + 375 WP_202714684.1 type II toxin-antitoxin system VapC family toxin Toxin
I6L76_RS16175 (I6L76_16175) 3345334..3346263 - 930 WP_059180559.1 formate dehydrogenase accessory protein FdhE -
I6L76_RS16180 (I6L76_16180) 3346260..3346895 - 636 WP_059180560.1 formate dehydrogenase cytochrome b556 subunit -
I6L76_RS16185 (I6L76_16185) 3346892..3347815 - 924 WP_015961045.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14075.20 Da        Isoelectric Point: 6.8808

>T207063 WP_202714684.1 NZ_CP077331:3344921-3345295 [Lelliottia amnigena]
MAKGSALFDTNILIDLFSGRAEAKHALESWPPQNAISIITWMEVMVGAKKYHQEHRTRIALSAFNVLDVSQEVAERSVDL
RQEYRMKLPDAIILATAQIHRLELVTRNTKDFANIPDVVTPYNL

Download         Length: 375 bp

>T207063 NZ_CP102869:1936733-1936835 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9492.66 Da        Isoelectric Point: 4.5022

>AT207063 WP_202668693.1 NZ_CP077331:3344679-3344921 [Lelliottia amnigena]
MMAGRDMGRILLDLSDEVIKRLDDLKVHRNVPRAELLREAVEQYLERHDQAESTISDALGLWHDCEEEGVDYQRKLREEW

Download         Length: 243 bp

>AT207063 NZ_CP102869:c1936842-1936697 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References