Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3225650..3226450 Replicon chromosome
Accession NZ_CP077331
Organism Lelliottia amnigena strain FDAARGOS 1446

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag I6L76_RS15655 Protein ID WP_216980720.1
Coordinates 3225650..3226033 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag I6L76_RS15660 Protein ID WP_216980721.1
Coordinates 3226091..3226450 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L76_RS15620 (I6L76_15620) 3220928..3222103 + 1176 WP_202668230.1 MFS transporter -
I6L76_RS15625 (I6L76_15625) 3222072..3223034 + 963 WP_216980716.1 HTH-type transcriptional regulator YidZ -
I6L76_RS15630 (I6L76_15630) 3223177..3223377 + 201 Protein_3058 phosphopantetheinyl transferase -
I6L76_RS15635 (I6L76_15635) 3223524..3223799 - 276 WP_216980717.1 type II toxin-antitoxin system RelE/ParE family toxin -
I6L76_RS15640 (I6L76_15640) 3223803..3224051 - 249 WP_004155191.1 ribbon-helix-helix domain-containing protein -
I6L76_RS15645 (I6L76_15645) 3224144..3224992 - 849 WP_216980718.1 DUF4942 domain-containing protein -
I6L76_RS15650 (I6L76_15650) 3225162..3225653 - 492 WP_216980719.1 DUF5983 family protein -
I6L76_RS15655 (I6L76_15655) 3225650..3226033 - 384 WP_216980720.1 TA system toxin CbtA family protein Toxin
I6L76_RS15660 (I6L76_15660) 3226091..3226450 - 360 WP_216980721.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I6L76_RS15665 (I6L76_15665) 3226482..3226703 - 222 WP_216980722.1 DUF987 domain-containing protein -
I6L76_RS15670 (I6L76_15670) 3226713..3227186 - 474 WP_216980723.1 DNA repair protein RadC -
I6L76_RS24020 3227196..3227381 - 186 Protein_3067 antirestriction protein -
I6L76_RS15680 (I6L76_15680) 3227451..3228571 + 1121 WP_142972780.1 IS3-like element ISSen4 family transposase -
I6L76_RS15685 (I6L76_15685) 3228805..3229167 - 363 WP_216980725.1 hypothetical protein -
I6L76_RS15690 (I6L76_15690) 3229200..3229640 - 441 WP_216980726.1 hypothetical protein -
I6L76_RS15695 (I6L76_15695) 3229653..3230339 - 687 WP_216980727.1 WYL domain-containing protein -
I6L76_RS15700 (I6L76_15700) 3230358..3231095 - 738 WP_216980728.1 DUF3944 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3223524..3236721 13197


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-116)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14203.09 Da        Isoelectric Point: 7.3580

>T207062 WP_216980720.1 NZ_CP077331:c3226033-3225650 [Lelliottia amnigena]
MQTLPLTPQRAASSCPSPVEIWQQLLTHLLGQHYGLTLSDTPFSNETTIREHIDAGISLSDAVNFLVEKYELVRTDRTGF
TIMEQSPFITSIDILRARQATGLTKRSSYKAVSDITRGKATRLEQSH

Download         Length: 384 bp

>T207062 NZ_CP102869:858049-858459 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13029.76 Da        Isoelectric Point: 6.6307

>AT207062 WP_216980721.1 NZ_CP077331:c3226450-3226091 [Lelliottia amnigena]
MKSVASAGISPEGNSCLQWGLSREVTPSFGARLVQEGNRLHFLADRAGFNGAFSEDDALRLDEAFPLMLKELELKLLSGK
LNPRHQHCVTLNHNGLTCEADSLGSHGYIYLTIYPASQK

Download         Length: 360 bp

>AT207062 NZ_CP102869:857802-858068 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References