Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RHH(antitoxin) |
| Location | 3223524..3224051 | Replicon | chromosome |
| Accession | NZ_CP077331 | ||
| Organism | Lelliottia amnigena strain FDAARGOS 1446 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | I6L76_RS15635 | Protein ID | WP_216980717.1 |
| Coordinates | 3223524..3223799 (-) | Length | 92 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | D4HV71 |
| Locus tag | I6L76_RS15640 | Protein ID | WP_004155191.1 |
| Coordinates | 3223803..3224051 (-) | Length | 83 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6L76_RS15615 (I6L76_15615) | 3219451..3220815 | + | 1365 | WP_202714117.1 | tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE | - |
| I6L76_RS15620 (I6L76_15620) | 3220928..3222103 | + | 1176 | WP_202668230.1 | MFS transporter | - |
| I6L76_RS15625 (I6L76_15625) | 3222072..3223034 | + | 963 | WP_216980716.1 | HTH-type transcriptional regulator YidZ | - |
| I6L76_RS15630 (I6L76_15630) | 3223177..3223377 | + | 201 | Protein_3058 | phosphopantetheinyl transferase | - |
| I6L76_RS15635 (I6L76_15635) | 3223524..3223799 | - | 276 | WP_216980717.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| I6L76_RS15640 (I6L76_15640) | 3223803..3224051 | - | 249 | WP_004155191.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
| I6L76_RS15645 (I6L76_15645) | 3224144..3224992 | - | 849 | WP_216980718.1 | DUF4942 domain-containing protein | - |
| I6L76_RS15650 (I6L76_15650) | 3225162..3225653 | - | 492 | WP_216980719.1 | DUF5983 family protein | - |
| I6L76_RS15655 (I6L76_15655) | 3225650..3226033 | - | 384 | WP_216980720.1 | TA system toxin CbtA family protein | - |
| I6L76_RS15660 (I6L76_15660) | 3226091..3226450 | - | 360 | WP_216980721.1 | type IV toxin-antitoxin system YeeU family antitoxin | - |
| I6L76_RS15665 (I6L76_15665) | 3226482..3226703 | - | 222 | WP_216980722.1 | DUF987 domain-containing protein | - |
| I6L76_RS15670 (I6L76_15670) | 3226713..3227186 | - | 474 | WP_216980723.1 | DNA repair protein RadC | - |
| I6L76_RS24020 | 3227196..3227381 | - | 186 | Protein_3067 | antirestriction protein | - |
| I6L76_RS15680 (I6L76_15680) | 3227451..3228571 | + | 1121 | WP_142972780.1 | IS3-like element ISSen4 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 3223524..3236721 | 13197 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 11131.48 Da Isoelectric Point: 5.9741
>T207061 WP_216980717.1 NZ_CP077331:c3223799-3223524 [Lelliottia amnigena]
MEIQWTQKAQDDLERIYRFACQYSRQHADNVLERLLIGTLGLADHPRIGVSQTRYEPREVRKILFDDYDVHYEIRHDTIY
IVDLWHTREDR
MEIQWTQKAQDDLERIYRFACQYSRQHADNVLERLLIGTLGLADHPRIGVSQTRYEPREVRKILFDDYDVHYEIRHDTIY
IVDLWHTREDR
Download Length: 276 bp
>T207061 NZ_CP102869:722586-723071 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA
Antitoxin
Download Length: 83 a.a. Molecular weight: 9121.53 Da Isoelectric Point: 8.7560
>AT207061 WP_004155191.1 NZ_CP077331:c3224051-3223803 [Lelliottia amnigena]
MRQLAKQTISAQIPAELAAAVENLAIELDRSKSWVIKEALTAMIEERERRHQQILKGLADVDAGRVVSHADVVDFANKLK
KS
MRQLAKQTISAQIPAELAAAVENLAIELDRSKSWVIKEALTAMIEERERRHQQILKGLADVDAGRVVSHADVVDFANKLK
KS
Download Length: 249 bp
>AT207061 NZ_CP102869:722296-722589 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|