Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3138020..3138739 Replicon chromosome
Accession NZ_CP077331
Organism Lelliottia amnigena strain FDAARGOS 1446

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag I6L76_RS15175 Protein ID WP_216980692.1
Coordinates 3138419..3138739 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag I6L76_RS15170 Protein ID WP_216980691.1
Coordinates 3138020..3138385 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L76_RS15140 (I6L76_15140) 3134318..3134752 + 435 WP_044488933.1 hypothetical protein -
I6L76_RS15145 (I6L76_15145) 3134865..3135704 + 840 WP_216980688.1 hypothetical protein -
I6L76_RS15150 (I6L76_15150) 3135763..3135954 + 192 WP_023305181.1 hypothetical protein -
I6L76_RS15155 (I6L76_15155) 3136397..3137218 + 822 WP_213813332.1 DUF932 domain-containing protein -
I6L76_RS15160 (I6L76_15160) 3137288..3137758 + 471 WP_216980689.1 DNA repair protein RadC -
I6L76_RS15165 (I6L76_15165) 3137767..3137988 + 222 WP_216980690.1 DUF987 family protein -
I6L76_RS15170 (I6L76_15170) 3138020..3138385 + 366 WP_216980691.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I6L76_RS15175 (I6L76_15175) 3138419..3138739 + 321 WP_216980692.1 TA system toxin CbtA family protein Toxin
I6L76_RS15180 (I6L76_15180) 3139141..3139701 + 561 WP_216980693.1 toll/interleukin-1 receptor domain-containing protein -
I6L76_RS15185 (I6L76_15185) 3139754..3140590 + 837 WP_216980694.1 DUF6430 domain-containing protein -
I6L76_RS15190 (I6L76_15190) 3140604..3140795 - 192 WP_032634623.1 toxin-antitoxin system HicB family antitoxin -
I6L76_RS15195 (I6L76_15195) 3140921..3141211 + 291 WP_216980695.1 SymE family type I addiction module toxin -
I6L76_RS15200 (I6L76_15200) 3141396..3141758 + 363 WP_216981890.1 type II toxin-antitoxin system RelE/ParE family toxin -
I6L76_RS15205 (I6L76_15205) 3141742..3142041 + 300 WP_202694508.1 XRE family transcriptional regulator -
I6L76_RS15210 (I6L76_15210) 3142110..3143108 - 999 WP_216980696.1 class I SAM-dependent methyltransferase -
I6L76_RS15215 (I6L76_15215) 3143202..3143726 - 525 WP_059180518.1 lipocalin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3119395..3164320 44925


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(5-104)

Antitoxin

Antitoxin CbeA

(18-116)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12218.82 Da        Isoelectric Point: 6.3229

>T207059 WP_216980692.1 NZ_CP077331:3138419-3138739 [Lelliottia amnigena]
MHISTVPATVTVSSRLSPVQVWRKLLTYILEHHYGLTINDTPFSNDTTIQEHIEAGVNLTDAVNFLVERFELVRIDQKGF
SWQDQEPWITSLDVHRAQFNLGLKRS

Download         Length: 321 bp

>T207059 NZ_CP102869:326096-326464 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGCGGATGA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13530.23 Da        Isoelectric Point: 6.4667

>AT207059 WP_216980691.1 NZ_CP077331:3138020-3138385 [Lelliottia amnigena]
MQSTTISGTSAEDTSCLQWGLKRNITPCFGARLIQEGNRLYFLADRAGFNGSFSDDEALRLDQAFPLMMKQLERMLTTGE
LDPRSQHCVTRHHNGLTCEADTIGSHGYVYIAIYPQSALNR

Download         Length: 366 bp

>AT207059 NZ_CP102869:325878-326099 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References