Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 2929092..2929689 Replicon chromosome
Accession NZ_CP077331
Organism Lelliottia amnigena strain FDAARGOS 1446

Toxin (Protein)


Gene name PumA Uniprot ID A0A3S5XVP2
Locus tag I6L76_RS14140 Protein ID WP_059179822.1
Coordinates 2929092..2929409 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A3S5XWI6
Locus tag I6L76_RS14145 Protein ID WP_059179821.1
Coordinates 2929402..2929689 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L76_RS14120 (I6L76_14120) 2925311..2926660 + 1350 WP_059179826.1 lysine-sensitive aspartokinase 3 -
I6L76_RS14125 (I6L76_14125) 2926753..2927697 + 945 WP_216980615.1 ketopantoate/pantoate/pantothenate transporter PanS -
I6L76_RS14130 (I6L76_14130) 2927760..2928032 + 273 WP_059179824.1 DUF3811 domain-containing protein -
I6L76_RS14135 (I6L76_14135) 2928033..2928902 - 870 WP_202694629.1 23S rRNA pseudouridine(2604) synthase RluF -
I6L76_RS14140 (I6L76_14140) 2929092..2929409 + 318 WP_059179822.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6L76_RS14145 (I6L76_14145) 2929402..2929689 + 288 WP_059179821.1 putative addiction module antidote protein Antitoxin
I6L76_RS14150 (I6L76_14150) 2929686..2931317 - 1632 WP_059179820.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(1-96)

Antitoxin

Uncharacterized protein HI1420

(3-90)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11914.68 Da        Isoelectric Point: 9.5735

>T207058 WP_059179822.1 NZ_CP077331:2929092-2929409 [Lelliottia amnigena]
MKEIVQTESFRCWEQNVNDPRAKTLIAARLFRLANGLPGDVKPVGEGISELRIHYGPGYRIYFKSQGNVLIILLSGGNKN
SQDKDIILAKTLARSLEHREFIHHD

Download         Length: 318 bp

>T207058 NZ_CP102866:c1275561-1274815 [Bacillus velezensis]
ATGCTTTTGTTTTTTCAGATCATGGTGTGGACGATGGCGGCCGCACTCATTTTATATGTGTACGCATCCTGGCGGTATGA
GGCAAAGGTAAAAGAAAAAATGTTTGCCATCCGTAAAACGTGGTATTTACTATTTGTACTGGGCTCCATGGTCTATTGGA
CATATGATCCTGAATCGCTCTTTGCCGCATGGAGACAATATTTGATTGTTGCCGTCTGCTTTGCCCTTATTGATGCGTTT
ATCTTTTTGAGCGCGTATATCAAAAAGCTCGCCGGCAATGAATTAGAGACGGATACGCGGGAAATTTTAGAAGAAAATAA
CGAAATGCTTCACTCCTATCTTGAAAAACTGAAAACCTATCAATATCTGTTGAAAAATGAACCGATCCATGTATATTATG
GAAGTACAGAAGCTTATGCGGAAGGCATCAGCAGACTGCTGGCCGCTTATGCCGAAAAAATGAATGTCACGGCTTCCTTG
TGCGACTATTCCGCACAATCGGATAAGGACCGCTTGACGGAGCATATGCCTGATGCGGCAGACGTTCAGTCCCGTCTTAA
CCGTAAAGACGTCTACTATGATCAAAAAGGCAGGCTTGTGCTTATTCCGTTTACAGTCCAGAACCGCCATTACGTGATCA
AACTCACGTCGGAAAACCTGTTGACGGAATTCGATTATTTGCTTTTCACATCGCTAACGAGCATTTATGATTTAATGCTG
CCAATAGAAGAGGAAGGTGACGGTTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10166.62 Da        Isoelectric Point: 5.0492

>AT207058 WP_059179821.1 NZ_CP077331:2929402-2929689 [Lelliottia amnigena]
MTELTHYDPARALINDDEISVFMADALETGDSAYIAKALGIVARAKGMSTIATQTGLSREQLYRSFSEKGNPTLKTTLAV
MKALGLGLTIKSAED

Download         Length: 288 bp

>AT207058 NZ_CP102866:c1274814-1274644 [Bacillus velezensis]
ATGGAGCAGGCATTTCAAAACGGGCAGCCGGAACAAAGAGCGAAACCGTTTAAAATGTTTAAAAAACGTTCAATGACAAG
TATCGCAAGTTACCAGGTCAGCCCTCATACCGCCAGAATTTTCAAAGAAAACGAGCGGCTGATTGACAAGTATAAACAAA
AAAAAGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5XVP2

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5XWI6

References