Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2135847..2136467 Replicon chromosome
Accession NZ_CP077331
Organism Lelliottia amnigena strain FDAARGOS 1446

Toxin (Protein)


Gene name Hha Uniprot ID A0A2S5C408
Locus tag I6L76_RS10280 Protein ID WP_012016344.1
Coordinates 2136249..2136467 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A3S5XLQ2
Locus tag I6L76_RS10275 Protein ID WP_059177928.1
Coordinates 2135847..2136221 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L76_RS10265 (I6L76_10265) 2130966..2132138 + 1173 WP_216981781.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
I6L76_RS10270 (I6L76_10270) 2132182..2135331 + 3150 WP_059177929.1 multidrug efflux RND transporter permease subunit AcrB -
I6L76_RS10275 (I6L76_10275) 2135847..2136221 + 375 WP_059177928.1 Hha toxicity modulator TomB Antitoxin
I6L76_RS10280 (I6L76_10280) 2136249..2136467 + 219 WP_012016344.1 HHA domain-containing protein Toxin
I6L76_RS10285 (I6L76_10285) 2136682..2137233 + 552 WP_059177927.1 maltose O-acetyltransferase -
I6L76_RS10290 (I6L76_10290) 2137352..2137819 + 468 WP_059177926.1 YlaC family protein -
I6L76_RS10295 (I6L76_10295) 2137791..2139251 - 1461 WP_202713808.1 PLP-dependent aminotransferase family protein -
I6L76_RS10300 (I6L76_10300) 2139351..2140061 + 711 WP_216981782.1 GNAT family protein -
I6L76_RS10305 (I6L76_10305) 2140058..2140198 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
I6L76_RS10310 (I6L76_10310) 2140201..2140461 - 261 WP_202713810.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8631.05 Da        Isoelectric Point: 8.9039

>T207056 WP_012016344.1 NZ_CP077331:2136249-2136467 [Lelliottia amnigena]
MSDKPLTKTDYLMRLRRCQSLDTLERVIEKNKYELPDHELAVFYSAADHRLAELTMNKLYDKIPVSVWKFVR

Download         Length: 219 bp

>T207056 NZ_CP102865:4411286-4411636 [Paenibacillus polymyxa]
TTGATCGTAAAGCGCGGCGACGTTTTTTTTGCAGACCTTTCACCCGTAGTCGGTTCCGAGCAAGGTGGCGTCAGACCTGT
GCTGATCATTCAAAATGATATCGGCAACCGGTTTAGCCCTACCGTGATCGTAGCAGCCATCACAGCACAGATTCAGAAGG
CAAAGCTGCCTACACACGTGGAAATCGACGCGGCGACGCATGGCTTTGATCGTGATTCTGTTGTTCTTCTAGAGCAAATC
CGGACGATCGACAAGCAAAGGCTTACCGACAAAATCACCCATTTGGATGAAGAAACCATGCGCAAAGTGAGCGATTCGCT
ACAGATCAGTCTCGGTTTGATTGATTTTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14550.26 Da        Isoelectric Point: 5.1481

>AT207056 WP_059177928.1 NZ_CP077331:2135847-2136221 [Lelliottia amnigena]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFNNVSRANPVSHSC

Download         Length: 375 bp

>AT207056 NZ_CP102865:4411028-4411279 [Paenibacillus polymyxa]
ATGATCAGTTTGCCAGATCATCTCTTGCAGGAAGTGGACGGGATCGTAGCTATGGAGAATTCCAACCGCAGTGAATTTAT
CAGGCAGGCAATGAAGCTTTATGTAGGTGAACGTAAAAAACGTTACATTCGTGAAGCTATGCAGCGTGGATACATGGAAA
TGGCTAAAATTAACCTGACCATGGCATCTGAAGCCTTTCACGCGGAGGAAGATGCAAACAGCACCTTGGGCCGTACAGTT
AGCGGGGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S5C408

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5XLQ2

References