Detailed information of TA system TA207055

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 953555..955114
• Replicon: chromosome
• Accession: NZ_CP077331
• Organism: Lelliottia amnigena strain FDAARGOS 1446

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: I6L76_RS04485
• Protein ID: WP_216981372.1
• Coordinates: 953807..955114 (+)
• Length: 436 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: I6L76_RS04480
• Protein ID: WP_216981371.1
• Coordinates: 953555..953806 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6L76_RS04460 (I6L76_04460)	949137..950099	-	963	WP_216981368.1	mannuronate-specific alginate lyase	-
I6L76_RS04465 (I6L76_04465)	950251..951768	+	1518	WP_216981369.1	alpha/beta hydrolase	-
I6L76_RS04470 (I6L76_04470)	951701..952909	-	1209	WP_216981370.1	MFS transporter	-
I6L76_RS04475 (I6L76_04475)	953003..953467	+	465	WP_174341810.1	helix-turn-helix domain-containing protein	-
I6L76_RS04480 (I6L76_04480)	953555..953806	+	252	WP_216981371.1	helix-turn-helix domain-containing protein	Antitoxin
I6L76_RS04485 (I6L76_04485)	953807..955114	+	1308	WP_216981372.1	type II toxin-antitoxin system HipA family toxin	Toxin
I6L76_RS04490 (I6L76_04490)	955255..956475	+	1221	WP_216981373.1	diguanylate phosphodiesterase	-
I6L76_RS04495 (I6L76_04495)	956518..957279	+	762	WP_202665385.1	thiol:disulfide interchange protein DsbG	-
I6L76_RS04500 (I6L76_04500)	957292..958599	-	1308	WP_216981374.1	glycoside hydrolase family 10 protein	-
I6L76_RS04505 (I6L76_04505)	958607..958894	-	288	WP_202666733.1	VF530 family protein	-
I6L76_RS04510 (I6L76_04510)	959259..959702	-	444	WP_202693422.1	cyclophilin-like fold protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (5-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (10-64)

Sequences

Toxin

Protein

• Length: 436 a.a.
• Molecular weight: 49182.29 Da
• Isoelectric Point: 8.6915

>T207055 WP_216981372.1 NZ_CP077331:953807-955114 [Lelliottia amnigena]
MKTSKLTVAMNGTVVGTLYRNGKGAMSWQYAQTWLDTPGARVISQSLPLTPRRQEGEVVYNFFSNLLPDSQAIISRMQTR
FKIPTDHPFDLLASVGRDCVGAIQLYPENSEIPPVTHMQATPLSDNEIAALLEGYRNAPLGMNDDQDFRISIAGAQEKTA
LLWHQNRWQRPNGSTPTSHIFKLPIGKIEQNNIDLSESCENEWLCLRLAREFGFSVAEATLATYADKKVLIVERFDRKWS
RDGKWLMRLPQEDMCQALGYSPALKYESHGGPGIAEIMTLLLGSRRSNQDRETFFRTQIFYWLTGAIDGHAKNYSVFIEP
DSAYVMTPLYDILSAYPVFGPKGISAQKAKMAMALQGKNRQYHWAQIQPRHFPATAERVGFSALRAKKMMIEMGNATNEI
IERVRQSLPIDFPTHISEAIFNGMAKQAERLIRLE

Nucleotide

• Length: 1308 bp

>T207055 NZ_CP102859:374145-374528 [Lacticaseibacillus paracasei]
ATGGATGTGTCCGTAAAACGCGGCGATGTTTTTTTCGCCGATCTGTCTCCGGTTGTCGGCTCCGAACAAGGCGGCAACCG
GCCAGTACTTATTATTCAAAACAACGTTGGCAACCATTACAGTCCCACAGTGATTGTGGCAGCCATTACCTCCAAGATTC
AAAAACCCAAGATGCCGACGCATGTCGGGTTACGGGCCAAGCAAGATGGCGTTGAACGCAACTCGGTCATTTTACTTGAG
CAAATTCGCACGATTGACAAGCAACGGCTACAAGCCCGCGTGACAGCTCTGTCAAGCACCAAAATGGCAGCAGTCGACCG
CGCGTTGGCGATTTCAGTGGGTCTGGTCAGTTTGCCCAAGCCCAAAACATATAATAAGAATTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9384.66 Da
• Isoelectric Point: 5.8173

>AT207055 WP_216981371.1 NZ_CP077331:953555-953806 [Lelliottia amnigena]
MKITTSTMLANAMRNQRKALELTQAEAAERVGMKQTTVSGFEQNPDTSKLETLFRLLSALDLELHVMPRGQTSEKDSGWT
QEW

Nucleotide

• Length: 252 bp

>AT207055 NZ_CP102859:373877-374125 [Lacticaseibacillus paracasei]
ATGAAAAAGCAAACGTCAGTAGCGGTAACGTTTGATGATGCCATTAAGGCGCGGTTGGATGCCTATTGTGAATTGAATGA
CATTGACGCTCAGGCTGTGATTACGGAGGCAGTGGCGACATTTTTGAAGTCACAGGCTCCCGAAATCAACCAATTGATTT
CTGGCTATGTAGCAATGGGCCAGATCAATACAGAGATCAGTCATGCTTTCTCTGCCTGCGAGAGCGAGGCATACGCCCAT
ATTCGATGA