Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 31406..31941 Replicon plasmid unnamed2
Accession NZ_CP077319
Organism Providencia rettgeri strain FDAARGOS 1450

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag I6L80_RS21530 Protein ID WP_115167506.1
Coordinates 31406..31693 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag I6L80_RS21535 Protein ID WP_282561821.1
Coordinates 31678..31941 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L80_RS21490 (I6L80_21490) 26457..26702 - 246 WP_217007971.1 DinI-like family protein -
I6L80_RS21495 (I6L80_21495) 27035..28102 + 1068 WP_282561820.1 replication initiation protein -
I6L80_RS21500 (I6L80_21500) 28099..28320 - 222 WP_217007973.1 hypothetical protein -
I6L80_RS21505 (I6L80_21505) 28441..29424 + 984 Protein_36 recombinase RecA -
I6L80_RS21510 (I6L80_21510) 29539..29766 - 228 WP_115167504.1 hypothetical protein -
I6L80_RS21515 (I6L80_21515) 29938..30120 + 183 WP_115168302.1 type II toxin-antitoxin system HicA family toxin -
I6L80_RS21520 (I6L80_21520) 30146..30574 + 429 WP_140187415.1 hypothetical protein -
I6L80_RS21525 (I6L80_21525) 30628..31392 - 765 WP_115167505.1 hypothetical protein -
I6L80_RS21530 (I6L80_21530) 31406..31693 - 288 WP_115167506.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6L80_RS21535 (I6L80_21535) 31678..31941 - 264 WP_282561821.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
I6L80_RS21540 (I6L80_21540) 32751..33140 + 390 WP_195848633.1 replication/maintenance protein RepL -
I6L80_RS21550 (I6L80_21550) 33690..35363 + 1674 WP_282561822.1 PD-(D/E)XK nuclease-like domain-containing protein -
I6L80_RS21555 (I6L80_21555) 35291..36481 + 1191 WP_115167510.1 recombinase RecT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..40804 40804


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11103.18 Da        Isoelectric Point: 10.6493

>T207046 WP_115167506.1 NZ_CP077319:c31693-31406 [Providencia rettgeri]
VMYSVKFRKDAEKEWKKLDKTIQSQFAKQLIKRCENPHIASAKLKNMPNCYKIKLRASGFRLVYQVMDDVLIIAVVAVGK
RERSQVYNLASERLK

Download         Length: 288 bp

>T207046 NZ_CP102853:c4500542-4500231 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTTTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTATTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9570.90 Da        Isoelectric Point: 4.0548

>AT207046 WP_282561821.1 NZ_CP077319:c31941-31678 [Providencia rettgeri]
MPNTILSDTSASVSELKKNPMATVNAGLGYPVAILNRNQPAFYCVPAELYEQMLDALDDNELANLVKERESQPLVDINLN
EYLCIR

Download         Length: 264 bp

>AT207046 NZ_CP102853:c4500230-4499940 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References