Detailed information of TA system TA207043

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pasABC/RelE-HTH
• Location: 46709..47183
• Replicon: plasmid unnamed1
• Accession: NZ_CP077318
• Organism: Providencia rettgeri strain FDAARGOS 1450

Toxin (Protein)

• Gene name: pasB
• Uniprot ID: -
• Locus tag: I6L80_RS20980
• Protein ID: WP_115168402.1
• Coordinates: 46917..47183 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: -
• Locus tag: I6L80_RS20975
• Protein ID: WP_115168403.1
• Coordinates: 46709..46933 (+)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6L80_RS20955 (I6L80_20955)	42589..44586	-	1998	WP_115168407.1	choline BCCT transporter BetT	-
I6L80_RS20960 (I6L80_20960)	44746..45375	-	630	WP_217007966.1	recombinase family protein	-
I6L80_RS20965 (I6L80_20965)	45579..45872	-	294	WP_282561815.1	cytoplasmic protein	-
I6L80_RS20970 (I6L80_20970)	45898..46476	-	579	WP_115168404.1	recombinase family protein	-
I6L80_RS20975 (I6L80_20975)	46709..46933	+	225	WP_115168403.1	TraY domain-containing protein	Antitoxin
I6L80_RS20980 (I6L80_20980)	46917..47183	+	267	WP_115168402.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I6L80_RS20985 (I6L80_20985)	47325..47891	-	567	WP_254178941.1	hypothetical protein	-
I6L80_RS20990 (I6L80_20990)	48143..48727	-	585	WP_115168401.1	Ail/Lom family outer membrane beta-barrel protein	-
I6L80_RS20995 (I6L80_20995)	48847..50565	+	1719	WP_217007967.1	ShlB/FhaC/HecB family hemolysin secretion/activation protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..108549	108549
	-	flank	IS/Tn	-	-	45898..46476	578

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

• Relaxosome protein TraY (4-45)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10387.05 Da
• Isoelectric Point: 8.9099

>T207043 WP_115168402.1 NZ_CP077318:46917-47183 [Providencia rettgeri]
MVWTISYSERALKSLRKMDKQNARRIVDFMDLRIAALDDPRLSGKPLKGELGEFWRYRVGDYRILCEIRDDELVILAATI
GHRKEVYD

Nucleotide

• Length: 267 bp

>T207043 NZ_CP102853:3662558-3662836 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8454.51 Da
• Isoelectric Point: 4.6652

>AT207043 WP_115168403.1 NZ_CP077318:46709-46933 [Providencia rettgeri]
MLAIRLSDDIESRLESLAKLTGRTKTFYAREAIVTHLEDLEDYYLSAETVAKIRRGEELVHSSEDVRKTLGLDD

Nucleotide

• Length: 225 bp

>AT207043 NZ_CP102853:3662295-3662555 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA