Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1939085..1939742 Replicon chromosome
Accession NZ_CP077317
Organism Providencia rettgeri strain FDAARGOS 1450

Toxin (Protein)


Gene name cptA Uniprot ID A0A6G6PHM2
Locus tag I6L80_RS08740 Protein ID WP_042851636.1
Coordinates 1939332..1939742 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6G6PHM9
Locus tag I6L80_RS08735 Protein ID WP_004913039.1
Coordinates 1939085..1939351 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L80_RS08720 (I6L80_08720) 1936081..1936977 - 897 WP_198641448.1 hypothetical protein -
I6L80_RS08725 (I6L80_08725) 1937222..1937842 - 621 WP_109912916.1 HD domain-containing protein -
I6L80_RS08730 (I6L80_08730) 1937854..1938837 - 984 WP_217007918.1 tRNA-modifying protein YgfZ -
I6L80_RS08735 (I6L80_08735) 1939085..1939351 + 267 WP_004913039.1 FAD assembly factor SdhE Antitoxin
I6L80_RS08740 (I6L80_08740) 1939332..1939742 + 411 WP_042851636.1 protein YgfX Toxin
I6L80_RS08745 (I6L80_08745) 1939832..1940350 - 519 WP_004913034.1 flavodoxin FldB -
I6L80_RS08750 (I6L80_08750) 1940468..1941370 + 903 WP_109912915.1 site-specific tyrosine recombinase XerD -
I6L80_RS08755 (I6L80_08755) 1941392..1942096 + 705 WP_109912946.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I6L80_RS08760 (I6L80_08760) 1942106..1943839 + 1734 WP_115166893.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15612.59 Da        Isoelectric Point: 10.7733

>T207041 WP_042851636.1 NZ_CP077317:1939332-1939742 [Providencia rettgeri]
VVLWKSNLSISWKTQLFSTCVHGVIGMFLLLTPWSPGNSMIWLPLLVVVVASWAKSQKNISKIKGVAVLVNGNKLQWKKN
EWRILKAPWLTRYGILLTLEALQGKPQKIHLWVAKDALSEENWRNLNQLLLQYPDI

Download         Length: 411 bp

>T207041 NZ_CP102853:3446608-3446826 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10674.24 Da        Isoelectric Point: 4.8780

>AT207041 WP_004913039.1 NZ_CP077317:1939085-1939351 [Providencia rettgeri]
MDIENKARIHWACRRGMRELDISIMPFFEYEYDNLTTQDKQVFVRLLECADPDLFNWLMNHGRPDDDELFRMIKLIQEKN
KNRGPVEI

Download         Length: 267 bp

>AT207041 NZ_CP102853:3446208-3446582 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6G6PHM2

Antitoxin

Source ID Structure
AlphaFold DB A0A6G6PHM9

References