Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1319006..1319652 Replicon chromosome
Accession NZ_CP077317
Organism Providencia rettgeri strain FDAARGOS 1450

Toxin (Protein)


Gene name Hha Uniprot ID B6XA97
Locus tag I6L80_RS06030 Protein ID WP_004905417.1
Coordinates 1319006..1319209 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag I6L80_RS06035 Protein ID WP_115166653.1
Coordinates 1319284..1319652 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L80_RS06005 (I6L80_06005) 1315103..1315441 + 339 WP_004905421.1 P-II family nitrogen regulator -
I6L80_RS06010 (I6L80_06010) 1315491..1316738 + 1248 WP_228367686.1 ammonium transporter AmtB -
I6L80_RS06015 (I6L80_06015) 1316877..1317746 - 870 WP_115166652.1 acyl-CoA thioesterase II -
I6L80_RS06020 (I6L80_06020) 1317986..1318444 + 459 WP_004914482.1 YbaY family lipoprotein -
I6L80_RS06030 (I6L80_06030) 1319006..1319209 - 204 WP_004905417.1 HHA domain-containing protein Toxin
I6L80_RS06035 (I6L80_06035) 1319284..1319652 - 369 WP_115166653.1 Hha toxicity modulator TomB Antitoxin
I6L80_RS06040 (I6L80_06040) 1320176..1321546 - 1371 WP_217007893.1 murein transglycosylase D -
I6L80_RS06045 (I6L80_06045) 1321628..1322383 - 756 WP_217007894.1 hydroxyacylglutathione hydrolase -
I6L80_RS06050 (I6L80_06050) 1322424..1323158 + 735 WP_004914475.1 methyltransferase domain-containing protein -
I6L80_RS06055 (I6L80_06055) 1323155..1323625 - 471 WP_004914473.1 ribonuclease HI -
I6L80_RS06060 (I6L80_06060) 1323680..1324441 + 762 WP_115166654.1 DNA polymerase III subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8061.34 Da        Isoelectric Point: 6.9770

>T207040 WP_004905417.1 NZ_CP077317:c1319209-1319006 [Providencia rettgeri]
MTKSDYLMRLRKCTTIETLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

>T207040 NZ_CP102853:2682242-2682349 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14076.03 Da        Isoelectric Point: 4.3849

>AT207040 WP_115166653.1 NZ_CP077317:c1319652-1319284 [Providencia rettgeri]
MDEYSPKRHDIAELKYLCNSLNRDAILSLQKTNTHWINDLSSPQSAALNELIEHIAAFVWRFKIKYPKENLVISLIEEYL
DETYDLFGSPVITLSEIIDWEAMNQSLVAVLDDDLKCLTSKT

Download         Length: 369 bp

>AT207040 NZ_CP102853:c2682189-2682128 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A291E6Q2

Antitoxin

Source ID Structure

References