Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/COG3657-dnstrm_HI1420
Location 325002..325585 Replicon chromosome
Accession NZ_CP077317
Organism Providencia rettgeri strain FDAARGOS 1450

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag I6L80_RS01625 Protein ID WP_115168161.1
Coordinates 325283..325585 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag I6L80_RS01620 Protein ID WP_004265229.1
Coordinates 325002..325286 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L80_RS01595 (I6L80_01595) 320157..321134 - 978 WP_004265237.1 6-phosphofructokinase -
I6L80_RS01600 (I6L80_01600) 321540..322484 - 945 WP_115168160.1 phosphatidate cytidylyltransferase -
I6L80_RS01605 (I6L80_01605) 322481..323122 - 642 WP_102140622.1 lysophospholipid acyltransferase family protein -
I6L80_RS01610 (I6L80_01610) 323360..324112 - 753 WP_004907010.1 M48 family metallopeptidase -
I6L80_RS01615 (I6L80_01615) 324339..324920 - 582 WP_004907006.1 HutD family protein -
I6L80_RS01620 (I6L80_01620) 325002..325286 - 285 WP_004265229.1 putative addiction module antidote protein Antitoxin
I6L80_RS01625 (I6L80_01625) 325283..325585 - 303 WP_115168161.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6L80_RS01630 (I6L80_01630) 325894..326625 + 732 WP_102140617.1 hypothetical protein -
I6L80_RS01635 (I6L80_01635) 326658..326876 - 219 WP_115168162.1 ogr/Delta-like zinc finger family protein -
I6L80_RS01640 (I6L80_01640) 326948..328045 - 1098 WP_217007835.1 phage late control D family protein -
I6L80_RS01645 (I6L80_01645) 328042..328488 - 447 WP_102140831.1 phage tail protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 325002..365241 40239


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-93)

Antitoxin

Uncharacterized protein HI1420

(3-91)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11420.37 Da        Isoelectric Point: 10.0723

>T207039 WP_115168161.1 NZ_CP077317:c325585-325283 [Providencia rettgeri]
MITVLTTECFDSWIKNLRDIRAKTKILMRIRRLKNGNYGDVQPIGDGFSELRVHEGQGYRVYLKQKSNVIIILLCGGTKA
TQQKDIHKAKLLFGEVEGEL

Download         Length: 303 bp

>T207039 NZ_CP102853:2681706-2681813 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10454.13 Da        Isoelectric Point: 4.5983

>AT207039 WP_004265229.1 NZ_CP077317:c325286-325002 [Providencia rettgeri]
MNTKLKEFDIAEYLNSEEEIQMYLNEILEEGDPSLVLAALGDIAKARNMSQLAKEVGMSREGLYKALSGQGNPTFMTIIK
IVNSLGLKLQFKSI

Download         Length: 285 bp

>AT207039 NZ_CP102853:c2681653-2681592 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References