Detailed information of TA system TA207038

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1300477..1302050
• Replicon: chromosome
• Accession: NZ_CP077311
• Organism: Aeromonas sp. FDAARGOS 1405

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: I6L35_RS06165
• Protein ID: WP_139743359.1
• Coordinates: 1300731..1302050 (+)
• Length: 440 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A1Q8D8F6
• Locus tag: I6L35_RS06160
• Protein ID: WP_042013334.1
• Coordinates: 1300477..1300731 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6L35_RS06140 (I6L35_06140)	1295884..1296636	-	753	WP_042864680.1	hypothetical protein	-
I6L35_RS06145 (I6L35_06145)	1296636..1298423	-	1788	WP_103255138.1	P-loop NTPase fold protein	-
I6L35_RS06150 (I6L35_06150)	1299002..1299325	+	324	WP_216979802.1	hypothetical protein	-
I6L35_RS06155 (I6L35_06155)	1299322..1299939	-	618	WP_216979803.1	recombinase family protein	-
I6L35_RS06160 (I6L35_06160)	1300477..1300731	+	255	WP_042013334.1	helix-turn-helix domain-containing protein	Antitoxin
I6L35_RS06165 (I6L35_06165)	1300731..1302050	+	1320	WP_139743359.1	type II toxin-antitoxin system HipA family toxin	Toxin
I6L35_RS06170 (I6L35_06170)	1302474..1304456	-	1983	WP_216979804.1	Fe(3+)-hydroxamate ABC transporter permease FhuB	-
I6L35_RS06175 (I6L35_06175)	1304453..1305337	-	885	WP_216979805.1	ABC transporter substrate-binding protein	-
I6L35_RS06180 (I6L35_06180)	1305371..1306135	-	765	WP_216979806.1	ATP-binding cassette domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1292455..1302050	9595

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (150-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 440 a.a.
• Molecular weight: 49381.44 Da
• Isoelectric Point: 7.5018

>T207038 WP_139743359.1 NZ_CP077311:1300731-1302050 [Aeromonas sp. FDAARGOS 1405]
MANLAVYMNGYRVGTFTKTTSGAHQFQYHESWLAQPGSRPISLSMPLRHQAYRGDEAYNFFDNLLPDNTEVRNRVVARYQ
AASTQPFDLLSCIGQDSVGALQLVTEGHDVPDVRRIDYKALSDGELEQILTSYKSGIPLGMVREQEEFRISIAGAQEKTA
LLYLDGRWYLPLNATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKEFGLPVPHCFMMQVGQVKALAVERFDRR
YAADRSWIMRLPQEDFCQVLNVPSARKYESHGGPGITDIMKTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSVYPVFGGRGLNRRDAKLAMGLASSKGKKYAIEQIFPRHFFQTAKAVGFERSAMEEILTELANSV
DDVIKRVTQQLPAGFPDAISSTILEGLKARSARLIKGWD

Nucleotide

• Length: 1320 bp

>T207038 NZ_CP102853:2681170-2681277 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9323.64 Da
• Isoelectric Point: 7.9834

>AT207038 WP_042013334.1 NZ_CP077311:1300477-1300731 [Aeromonas sp. FDAARGOS 1405]
MKVTSAKQLSACIKDARLSQKLSQGKVAEKVGIRQDTVSSFELNPESTKLETLFKILASLELSLDIKPRNESSESPASGW
KEEW

Nucleotide

• Length: 255 bp

>AT207038 NZ_CP102853:c2681117-2681056 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Structures

Antitoxin

• AlphaFold DB: A0A1Q8D8F6