Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3290357..3290977 Replicon chromosome
Accession NZ_CP077308
Organism Enterobacter hormaechei strain FDAARGOS 1433

Toxin (Protein)


Gene name Hha Uniprot ID F5RUW8
Locus tag I6L63_RS16020 Protein ID WP_001291436.1
Coordinates 3290759..3290977 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag I6L63_RS16015 Protein ID WP_006809850.1
Coordinates 3290357..3290731 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L63_RS16005 (I6L63_16005) 3285486..3286679 + 1194 WP_006809848.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
I6L63_RS16010 (I6L63_16010) 3286702..3289848 + 3147 WP_006809849.1 multidrug efflux RND transporter permease subunit AcrB -
I6L63_RS16015 (I6L63_16015) 3290357..3290731 + 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
I6L63_RS16020 (I6L63_16020) 3290759..3290977 + 219 WP_001291436.1 HHA domain-containing protein Toxin
I6L63_RS16025 (I6L63_16025) 3291186..3291737 + 552 WP_006809851.1 maltose O-acetyltransferase -
I6L63_RS16030 (I6L63_16030) 3291854..3292321 + 468 WP_006809852.1 YlaC family protein -
I6L63_RS16035 (I6L63_16035) 3292357..3292497 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
I6L63_RS16040 (I6L63_16040) 3292500..3292760 - 261 WP_006809853.1 type B 50S ribosomal protein L31 -
I6L63_RS16045 (I6L63_16045) 3292978..3294546 + 1569 WP_006809854.1 EAL domain-containing protein -
I6L63_RS16050 (I6L63_16050) 3294539..3294811 - 273 WP_006809855.1 metal-sensing transcriptional repressor -
I6L63_RS16055 (I6L63_16055) 3294946..3295752 + 807 WP_032673625.1 nickel/cobalt efflux protein RcnA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8597.97 Da        Isoelectric Point: 8.9008

>T207033 WP_001291436.1 NZ_CP077308:3290759-3290977 [Enterobacter hormaechei]
MSEKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T207033 NZ_CP102853:1837628-1837879 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT207033 WP_006809850.1 NZ_CP077308:3290357-3290731 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT207033 NZ_CP102853:1837876-1838130 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T1VNQ1

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References