Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2026632..2027377 Replicon chromosome
Accession NZ_CP077308
Organism Enterobacter hormaechei strain FDAARGOS 1433

Toxin (Protein)


Gene name tacT Uniprot ID F5RXF6
Locus tag I6L63_RS09695 Protein ID WP_006810665.1
Coordinates 2026886..2027377 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A7T1VGI8
Locus tag I6L63_RS09690 Protein ID WP_032673836.1
Coordinates 2026632..2026898 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L63_RS09670 (I6L63_09670) 2022109..2023095 + 987 WP_006810670.1 DUF979 domain-containing protein -
I6L63_RS09675 (I6L63_09675) 2023105..2024100 + 996 WP_006810669.1 DUF2891 domain-containing protein -
I6L63_RS09680 (I6L63_09680) 2024121..2025509 - 1389 WP_032673838.1 MFS transporter -
I6L63_RS09685 (I6L63_09685) 2025638..2026543 + 906 WP_032673837.1 LysR family transcriptional regulator -
I6L63_RS09690 (I6L63_09690) 2026632..2026898 + 267 WP_032673836.1 DUF1778 domain-containing protein Antitoxin
I6L63_RS09695 (I6L63_09695) 2026886..2027377 + 492 WP_006810665.1 GNAT family N-acetyltransferase Toxin
I6L63_RS09700 (I6L63_09700) 2027416..2028414 - 999 WP_006810664.1 HAD family hydrolase -
I6L63_RS09705 (I6L63_09705) 2028411..2029424 - 1014 WP_006810663.1 BatD family protein -
I6L63_RS09710 (I6L63_09710) 2029421..2030935 - 1515 WP_006810662.1 VWA domain-containing protein -
I6L63_RS09715 (I6L63_09715) 2030932..2031909 - 978 WP_006810661.1 VWA domain-containing protein -
I6L63_RS09720 (I6L63_09720) 2031902..2032342 - 441 WP_006810660.1 DUF4381 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17773.46 Da        Isoelectric Point: 9.6044

>T207030 WP_006810665.1 NZ_CP077308:2026886-2027377 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGHLRRNM
PDPIPVIVLARLAVDVSLHGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTENAKAFYLHHGFKASQTQERTLFLRLP
QEK

Download         Length: 492 bp

>T207030 NZ_CP102853:862911-863318 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10090.50 Da        Isoelectric Point: 4.3837

>AT207030 WP_032673836.1 NZ_CP077308:2026632-2026898 [Enterobacter hormaechei]
MKSDVQLNIRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Download         Length: 267 bp

>AT207030 NZ_CP102853:862664-862930 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T1VG35

Antitoxin

Source ID Structure
AlphaFold DB A0A7T1VGI8

References