Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-MazE
Location 3292237..3292870 Replicon chromosome
Accession NC_003295
Organism Ralstonia solanacearum GMI1000

Toxin (Protein)


Gene name vapC Uniprot ID Q8XUX8
Locus tag RS_RS15350 Protein ID WP_011002948.1
Coordinates 3292237..3292650 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q8XUX7
Locus tag RS_RS15355 Protein ID WP_011002949.1
Coordinates 3292637..3292870 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RS_RS15330 3287613..3289355 + 1743 WP_011002944.1 ABC transporter substrate-binding protein -
RS_RS15335 3289517..3291013 + 1497 WP_011002945.1 glycerol kinase GlpK -
RS_RS15340 3291074..3291445 - 372 WP_011002946.1 hypothetical protein -
RS_RS15345 3291636..3292262 + 627 WP_011002947.1 DUF1415 domain-containing protein -
RS_RS15350 3292237..3292650 - 414 WP_011002948.1 PIN domain-containing protein Toxin
RS_RS15355 3292637..3292870 - 234 WP_011002949.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
RS_RS15360 3292927..3294534 - 1608 WP_043876668.1 glucan biosynthesis protein D -
RS_RS15365 3294729..3295979 + 1251 WP_119918750.1 AGE family epimerase/isomerase -
RS_RS15370 3295987..3297282 + 1296 WP_011002952.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-116)

Antitoxin

SpoVT-AbrB domain

(5-37)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15101.45 Da        Isoelectric Point: 5.5348

>T20703 WP_011002948.1 NC_003295:c3292650-3292237 [Ralstonia solanacearum GMI1000]
MPATEAFFDSNVVLYLLSADTAKADAAETLLMTGGVVTVQVLNETTHVMRRKLAMPWHAIETVQEAVRAQCRVEPLTLET
HDLGRRIAERYGLSVYDALIVAAALLAGCNVLYSEDMQHGLVIEQHLRIVNPFPARA

Download         Length: 414 bp

>T20703 NC_003295:c3292650-3292237 [Ralstonia solanacearum GMI1000]
ATGCCCGCGACTGAGGCATTCTTCGACAGCAATGTCGTGCTGTACCTGCTGTCGGCCGACACCGCCAAGGCCGATGCGGC
GGAAACGCTGCTGATGACCGGCGGTGTCGTCACCGTACAGGTACTGAACGAAACGACGCACGTGATGCGCCGCAAGCTCG
CCATGCCGTGGCACGCGATCGAAACGGTGCAGGAGGCCGTGCGTGCGCAATGCCGGGTCGAGCCGCTGACGCTCGAAACC
CATGATCTCGGACGGCGTATCGCAGAACGCTACGGATTGTCGGTCTATGATGCACTGATCGTCGCGGCGGCATTGCTTGC
CGGCTGCAACGTTCTGTATTCCGAGGATATGCAGCACGGCCTGGTGATCGAGCAGCATCTGCGCATCGTCAATCCTTTTC
CGGCACGGGCATGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8790.98 Da        Isoelectric Point: 8.7287

>AT20703 WP_011002949.1 NC_003295:c3292870-3292637 [Ralstonia solanacearum GMI1000]
MQVSKWGNSLAIRLPAAVVEALQLHEGDDVEVVIAGERSFGVRRKRAARELFDRIHQYRGKLPADFIFERDQANARD

Download         Length: 234 bp

>AT20703 NC_003295:c3292870-3292637 [Ralstonia solanacearum GMI1000]
ATGCAAGTCTCGAAATGGGGCAACAGCCTCGCTATCCGGCTGCCGGCGGCCGTTGTGGAGGCGCTTCAGCTGCACGAAGG
CGACGACGTCGAGGTGGTGATCGCGGGCGAGCGCTCGTTTGGCGTCCGCCGCAAGCGCGCTGCGCGCGAGCTTTTCGACC
GGATCCACCAATATCGCGGCAAGCTGCCCGCCGATTTCATCTTCGAGCGCGACCAGGCCAATGCCCGCGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q8XUX8

Antitoxin

Source ID Structure
AlphaFold DB A0A223GR76

References