Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 581500..582157 Replicon chromosome
Accession NZ_CP077308
Organism Enterobacter hormaechei strain FDAARGOS 1433

Toxin (Protein)


Gene name cptA Uniprot ID A0A7T1QL73
Locus tag I6L63_RS02880 Protein ID WP_032674037.1
Coordinates 581747..582157 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag I6L63_RS02875 Protein ID WP_003863437.1
Coordinates 581500..581766 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L63_RS02855 (I6L63_02855) 576933..578366 - 1434 WP_006811878.1 6-phospho-beta-glucosidase -
I6L63_RS02860 (I6L63_02860) 578483..579214 - 732 WP_006811877.1 MurR/RpiR family transcriptional regulator -
I6L63_RS02865 (I6L63_02865) 579481..580140 + 660 WP_006811875.1 hemolysin III family protein -
I6L63_RS02870 (I6L63_02870) 580225..581205 - 981 WP_006811874.1 tRNA-modifying protein YgfZ -
I6L63_RS02875 (I6L63_02875) 581500..581766 + 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
I6L63_RS02880 (I6L63_02880) 581747..582157 + 411 WP_032674037.1 protein YgfX Toxin
I6L63_RS02885 (I6L63_02885) 582159..582680 - 522 WP_006811872.1 flavodoxin FldB -
I6L63_RS02890 (I6L63_02890) 582782..583678 + 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
I6L63_RS02895 (I6L63_02895) 583707..584420 + 714 WP_006811871.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I6L63_RS02900 (I6L63_02900) 584426..586159 + 1734 WP_006811870.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16292.10 Da        Isoelectric Point: 11.1558

>T207023 WP_032674037.1 NZ_CP077308:581747-582157 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMTGTPWMLNTGMMLRLRRVEDNRREHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T207023 NZ_CP102850:c1981389-1981000 [Gordonia mangrovi]
GTGAGTCTCACCTATGTGGACACCTCTGCGGCGATGAAGTTGATCGTCGATGAGCCCGAGAGTGAGCCGCTGCTGAGTTC
CCTGACGTCGGCCCCGGCTCGGCGTCTGATCGCATCGTGGCTGCTACACGCCGAACTGCACTGTGCCGCCGGCCGATACC
CGGACGTGGTGAGTCCCGAGGCGCTTTCGGCTGTCCTCGCAACGATTGACCTCATCGACCTCACTCGGGGTGACATGATC
GCTGCGGGCACGTACGCCCCGCTCCGGTCGCACGATGCCATCCATCTCGCGGTCGCCATCCGGGTAGGTGCGGACGACTT
CCTCACCTACGACGATGAACTCGCTGCCCGCGCCAGTCGCGCCGGCTTGCGGGCGCTGTCTCCGCGCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT207023 WP_003863437.1 NZ_CP077308:581500-581766 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT207023 NZ_CP102850:c1981652-1981386 [Gordonia mangrovi]
ATGGAGTCGGTGACTCACCGTGAGATGCGCAACCGCAGCGCGGAGCTGCTCCGGCGCGTGGAGGCGGGGGAGTCGATCAT
CGTCACGAACAACGGGCGGCCGGTGGCTGTGATCAGTCCGCTCGAACGCCGCGTACTCGAGGAACTCGTCGACCAGGGCC
ATGTGCGACGAGCCACGCGCGCTGTCGCCGACCTCCGCGACATCGAACGCACCGCAAGTGCGTTGAGGACGGATCAGATC
CTCGACGACACCCGGGGCCACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T1QL73

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References