Detailed information of TA system TA207021

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 5348..5897
• Replicon: plasmid unnamed3
• Accession: NZ_CP077306
• Organism: Acinetobacter pittii strain FDAARGOS 1396

Toxin (Protein)

• Gene name: relE
• Uniprot ID: N9KJ78
• Locus tag: I6L26_RS18525
• Protein ID: WP_000176412.1
• Coordinates: 5607..5897 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: N9KCM7
• Locus tag: I6L26_RS18520
• Protein ID: WP_005140357.1
• Coordinates: 5348..5623 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6L26_RS18495 (I6L26_18495)	777..1937	-	1161	WP_000179382.1	MobA/MobL family protein	-
I6L26_RS18500 (I6L26_18500)	2244..3020	+	777	WP_000191151.1	hypothetical protein	-
I6L26_RS18505 (I6L26_18505)	3299..4444	+	1146	WP_226789423.1	hypothetical protein	-
I6L26_RS18510 (I6L26_18510)	4517..4759	-	243	WP_001015364.1	hypothetical protein	-
I6L26_RS18515 (I6L26_18515)	4908..5132	+	225	WP_002072934.1	hypothetical protein	-
I6L26_RS18520 (I6L26_18520)	5348..5623	+	276	WP_005140357.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
I6L26_RS18525 (I6L26_18525)	5607..5897	+	291	WP_000176412.1	type II toxin-antitoxin system YafQ family toxin	Toxin
I6L26_RS18530 (I6L26_18530)	5945..6091	-	147	WP_000192351.1	hypothetical protein	-
I6L26_RS18535 (I6L26_18535)	6088..6609	-	522	WP_000999915.1	hypothetical protein	-
I6L26_RS18540 (I6L26_18540)	7134..7451	-	318	WP_005065053.1	hypothetical protein	-
I6L26_RS18545 (I6L26_18545)	7802..8368	-	567	WP_000858429.1	plasmid replication DNA-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..9038	9038

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (4-96)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (9-75)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11187.12 Da
• Isoelectric Point: 6.9783

>T207021 WP_000176412.1 NZ_CP077306:5607-5897 [Acinetobacter pittii]
MTLTIRYKKQFKKDFKRVSSNPKLKKGLLILKDLIDEHLVKTGTVPDEYLPHPLIGEWKPHMECHILPDLLLIWDVDEDN
NELILARIGSHSELFG

Nucleotide

• Length: 291 bp

>T207021 NZ_CP102850:1025634-1025879 [Gordonia mangrovi]
GTGGTGCTGTCGAATTCGATCCATATCGCGGCGGATACCGGACGTATCATCGTGTGCCCCTACATTCCCGGACCGATCCC
CGAAGGCACGATGGCCATGGTCGTCGCCGTCGGAGAACCCGAGGGTGTGGCACTTCCCGAACTGGTGCAATGGCTTCCGG
TCACAGCCCTCGACGACCCGATCGGAAATATCGGCGCCGAGGCATTGCGCCAGGCCGTGGGACTGATGACTGCGTTGATC
ACGTAG

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10290.65 Da
• Isoelectric Point: 4.6702

>AT207021 WP_005140357.1 NZ_CP077306:5348-5623 [Acinetobacter pittii]
MNTLAKKDEYVRARVPNELKVQAERILKEVGLNTTDAIRLLLTQVVNRGGFPLELRTPNRTTIEAMNSVAEPKKFSSAQE
LFTDLEDDTDD

Nucleotide

• Length: 276 bp

>AT207021 NZ_CP102850:1025353-1025580 [Gordonia mangrovi]
ATGGCCAAGGATAAGGTGTCCATCACTCTCGACAGTGCGGTCTTGGCCACTGCCGACGCCGACGCGAAGGCAGCGGGTCT
GAATCGGTCTGAGCTGATCGAACGCGCGTTGCGACATGAACATCTTCGGATTGCTCTCACGAATTACACGACGCACACAG
TTCCGGCACTGAACATCGACGACTACGCCGACATGATCCATCAGGCAAACAAGGCTGCCGGCTTGTGA

Structures

Toxin

• AlphaFold DB: N9KJ78

Antitoxin

• AlphaFold DB: N9KCM7