Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 37238..37766 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP077304 | ||
| Organism | Acinetobacter pittii strain FDAARGOS 1396 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | B0V430 |
| Locus tag | I6L26_RS18170 | Protein ID | WP_000221360.1 |
| Coordinates | 37473..37766 (+) | Length | 98 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | B0V429 |
| Locus tag | I6L26_RS18165 | Protein ID | WP_000246757.1 |
| Coordinates | 37238..37483 (+) | Length | 82 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6L26_RS18135 (I6L26_18135) | 32640..33638 | + | 999 | WP_002120211.1 | zinc-binding alcohol dehydrogenase family protein | - |
| I6L26_RS18140 (I6L26_18140) | 33659..33943 | + | 285 | WP_000155817.1 | putative quinol monooxygenase | - |
| I6L26_RS18145 (I6L26_18145) | 34078..34299 | + | 222 | Protein_35 | IS3 family transposase | - |
| I6L26_RS18715 | 34303..34392 | + | 90 | Protein_36 | DNA-binding protein | - |
| I6L26_RS18150 (I6L26_18150) | 34709..35227 | + | 519 | WP_000447196.1 | tetratricopeptide repeat protein | - |
| I6L26_RS18155 (I6L26_18155) | 35359..35871 | + | 513 | WP_001089570.1 | SMI1/KNR4 family protein | - |
| I6L26_RS18160 (I6L26_18160) | 36079..36981 | + | 903 | WP_000466974.1 | hypothetical protein | - |
| I6L26_RS18165 (I6L26_18165) | 37238..37483 | + | 246 | WP_000246757.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| I6L26_RS18170 (I6L26_18170) | 37473..37766 | + | 294 | WP_000221360.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| I6L26_RS18175 (I6L26_18175) | 37953..38069 | + | 117 | Protein_42 | IS5/IS1182 family transposase | - |
| I6L26_RS18180 (I6L26_18180) | 39084..39392 | + | 309 | WP_000269910.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| I6L26_RS18185 (I6L26_18185) | 39433..39735 | + | 303 | WP_001140619.1 | XRE family transcriptional regulator | - |
| I6L26_RS18190 (I6L26_18190) | 39728..39937 | + | 210 | WP_000069470.1 | hypothetical protein | - |
| I6L26_RS18195 (I6L26_18195) | 40047..40274 | - | 228 | WP_000555567.1 | hypothetical protein | - |
| I6L26_RS18200 (I6L26_18200) | 41040..41343 | - | 304 | Protein_47 | XRE family transcriptional regulator | - |
| I6L26_RS18205 (I6L26_18205) | 41336..41692 | - | 357 | WP_000269908.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..94386 | 94386 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 98 a.a. Molecular weight: 11317.49 Da Isoelectric Point: 10.4753
>T207017 WP_000221360.1 NZ_CP077304:37473-37766 [Acinetobacter pittii]
MTYKLLRNKDFTAEWEKLPSAIRDQFKKKLAKVIEQPHIPKNMLRGDLTGCYKIKLLKTGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD
MTYKLLRNKDFTAEWEKLPSAIRDQFKKKLAKVIEQPHIPKNMLRGDLTGCYKIKLLKTGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD
Download Length: 294 bp
>T207017 NZ_CP102843:c991-677 [Klebsiella pneumoniae]
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGAGATTTACAACGCCTCCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGCCGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CATTTCTGCCGCTGGAATATCAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCGGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA
ATGCCACAGGTAACGATTTCCGCGCTGGCACAGCGAGATTTACAACGCCTCCAGGACTTTCTCAAAACCAAAAATCGGCT
GGCAGCCAGAAAAGCCGGTGAGGTGATCGTCCGGGCTATCCAGCAACTGAAAACATTGCCAGACATTGGCCGCCCGGTGC
CATTTCTGCCGCTGGAATATCAGGAACTGGTGATCGGGTTTGGCGACAGTGGCTATGTGATGCTCTACCGCCACGACCGG
GAAATGGACCGGATTGTGATCGTCACCGTCAGGCATCAGAAAGAATCCGGGTATCCGGGGGCAGACAGCCTCTAA
Antitoxin
Download Length: 82 a.a. Molecular weight: 9264.63 Da Isoelectric Point: 4.2821
>AT207017 WP_000246757.1 NZ_CP077304:37238-37483 [Acinetobacter pittii]
MATVNFRVDEALKEKSYSVLREQGIAPTEFFTNVLEYIAATGKLPVQKALLSEEDTELLAIVRKRMNDPKEMFEEITLDD
L
MATVNFRVDEALKEKSYSVLREQGIAPTEFFTNVLEYIAATGKLPVQKALLSEEDTELLAIVRKRMNDPKEMFEEITLDD
L
Download Length: 246 bp
>AT207017 NZ_CP102843:c1257-979 [Klebsiella pneumoniae]
ATGTCATCAGCAACATCCATCAGGCTCGATGAAGAACTTAAGGACCGGCTGAAAACGCTGGCCGATGACCGGCACCGCTC
AGCGCACGCGCTAATGCTGGAGGCAATCACCGAATACATCGACCGGGAAGAGAAGCGCAGCCAGTACCTGCGGGACGGAC
AAGCCGCATGGCAGCACTATCAGGAAACGGGTCTGCACCTTACTGCGGAAGAAGCAGAAGCCTGGATAAGTACCTGGGGA
ACTGAGAACGAGCAGGATGCTCCGCCATGCCACAGGTAA
ATGTCATCAGCAACATCCATCAGGCTCGATGAAGAACTTAAGGACCGGCTGAAAACGCTGGCCGATGACCGGCACCGCTC
AGCGCACGCGCTAATGCTGGAGGCAATCACCGAATACATCGACCGGGAAGAGAAGCGCAGCCAGTACCTGCGGGACGGAC
AAGCCGCATGGCAGCACTATCAGGAAACGGGTCTGCACCTTACTGCGGAAGAAGCAGAAGCCTGGATAAGTACCTGGGGA
ACTGAGAACGAGCAGGATGCTCCGCCATGCCACAGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829RR87 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A009MZ79 |