Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 3474785..3475438 Replicon chromosome
Accession NZ_CP077303
Organism Acinetobacter pittii strain FDAARGOS 1396

Toxin (Protein)


Gene name cptA Uniprot ID A0A009NMD1
Locus tag I6L26_RS16360 Protein ID WP_005804615.1
Coordinates 3474785..3475174 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A009HHW9
Locus tag I6L26_RS16365 Protein ID WP_002117064.1
Coordinates 3475181..3475438 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L26_RS16345 (I6L26_16345) 3469876..3472086 - 2211 WP_005804618.1 TRAP transporter large permease subunit -
I6L26_RS16350 (I6L26_16350) 3472266..3472841 - 576 WP_025464189.1 rhombosortase -
I6L26_RS16355 (I6L26_16355) 3472926..3474014 - 1089 WP_005804616.1 hypothetical protein -
I6L26_RS16360 (I6L26_16360) 3474785..3475174 - 390 WP_005804615.1 hypothetical protein Toxin
I6L26_RS16365 (I6L26_16365) 3475181..3475438 - 258 WP_002117064.1 succinate dehydrogenase assembly factor 2 Antitoxin
I6L26_RS16370 (I6L26_16370) 3475627..3476799 + 1173 WP_025464188.1 acyl-CoA dehydrogenase family protein -
I6L26_RS16375 (I6L26_16375) 3476850..3478340 - 1491 WP_002116796.1 NAD(P)/FAD-dependent oxidoreductase -
I6L26_RS16380 (I6L26_16380) 3478522..3478899 - 378 WP_002049717.1 50S ribosomal protein L17 -
I6L26_RS16385 (I6L26_16385) 3478918..3479925 - 1008 WP_002116730.1 DNA-directed RNA polymerase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15553.65 Da        Isoelectric Point: 8.7390

>T207016 WP_005804615.1 NZ_CP077303:c3475174-3474785 [Acinetobacter pittii]
MIKELNFELKYSRVSVIFQLFVGLGLAILLYQLLTPIWWLCAVILLFIGFIFFLKQAQISQIEYLDQKLWSIAYFSKKEI
YRGEITKIIDYQLFVVIYFEETPTNIAIVWFDQLPIQQWKRLKVLEKLY

Download         Length: 390 bp

>T207016 NZ_CP102842:c52208-51792 [Klebsiella pneumoniae]
GTGAAAAAGACTTTTATGCTCGACACAAAAATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGTGGCCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCCCCGCGCCATATCGAGCTGGTTGACGCGTTCTGTGCCCGCCTCGATGCCATCCTGCCCTGGGACCGAGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCCTTGCGACAGGCCGGGACGCCGATTGGCCCGAACGACACGGCGATAGC
CGGGCACGCCATCGCGGCCGGCGCCGTTCTGGTGACGAATAATGTAAGAGAGTTTGCGCGGGTCCCGGGCCTGGTGCTGG
AAGACTGGGTGAATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10295.73 Da        Isoelectric Point: 4.4809

>AT207016 WP_002117064.1 NZ_CP077303:c3475438-3475181 [Acinetobacter pittii]
MSDEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVDQEDPDLLDWFMEVSEPPRTELREFIYKLK
QYVHG

Download         Length: 258 bp

>AT207016 NZ_CP102842:c52435-52205 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGTGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAACGCGAGGATGTGGTCAGCGACGAAGGACGATTTGACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A009NMD1

Antitoxin

Source ID Structure
AlphaFold DB A0A009HHW9

References