Detailed information of TA system TA207015

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2750377..2751055
• Replicon: chromosome
• Accession: NZ_CP077303
• Organism: Acinetobacter pittii strain FDAARGOS 1396

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A837R0V9
• Locus tag: I6L26_RS12965
• Protein ID: WP_032810518.1
• Coordinates: 2750873..2751055 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: I6L26_RS12960
• Protein ID: WP_032006590.1
• Coordinates: 2750377..2750781 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6L26_RS12950 (I6L26_12950)	2745489..2749571	-	4083	WP_216978091.1	tape measure protein	-
I6L26_RS12955 (I6L26_12955)	2749696..2750295	-	600	WP_031968591.1	hypothetical protein	-
I6L26_RS12960 (I6L26_12960)	2750377..2750781	-	405	WP_032006590.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
I6L26_RS12965 (I6L26_12965)	2750873..2751055	-	183	WP_032810518.1	type II toxin-antitoxin system HicA family toxin	Toxin
I6L26_RS12970 (I6L26_12970)	2751124..2751384	-	261	WP_032042280.1	hypothetical protein	-
I6L26_RS12975 (I6L26_12975)	2751387..2751920	-	534	WP_031968588.1	hypothetical protein	-
I6L26_RS12980 (I6L26_12980)	2751966..2752895	-	930	WP_031968587.1	phage tail tube protein	-
I6L26_RS12985 (I6L26_12985)	2753004..2753216	-	213	WP_049069243.1	hypothetical protein	-
I6L26_RS12990 (I6L26_12990)	2753218..2753616	-	399	WP_057090128.1	phage tail terminator-like protein	-
I6L26_RS12995 (I6L26_12995)	2753618..2753986	-	369	WP_057090139.1	hypothetical protein	-
I6L26_RS13000 (I6L26_13000)	2753952..2754365	-	414	WP_049069240.1	hypothetical protein	-
I6L26_RS13005 (I6L26_13005)	2754377..2754547	-	171	WP_167468861.1	hypothetical protein	-
I6L26_RS13010 (I6L26_13010)	2754547..2754915	-	369	WP_216978092.1	glutamate 5-kinase	-
I6L26_RS13015 (I6L26_13015)	2754915..2755292	-	378	WP_057090125.1	hypothetical protein	-
I6L26_RS18665	2755296..2755895	-	600	WP_202890893.1	HeH/LEM domain protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2726581..2775461	48880

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6667.83 Da
• Isoelectric Point: 10.7364

>T207015 WP_032810518.1 NZ_CP077303:c2751055-2750873 [Acinetobacter pittii]
VKSLDLIKMIEADGWYQVRVTGSHHHFKHPTKKGLVTVPHPKKDLPSGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T207015 NZ_CP102842:35409-35741 [Klebsiella pneumoniae]
ATGGTATCTCGTTTTGTGCCGGATGCTGGCGACCTTATCTGGATAAATTTTGATCCCGTGGAAGGACATGAGCAAGGAGG
GCATCGCCCCGCAGTCGTGCTGAGTCCGTTTGCATACAACAACAAAACAGGTTTGTTGCTGTGCGTACCTTGCACAACAA
AAGTAAAAGGCTATCCCTTTGAAGTTGAATTGCCAGGAGAACGCGATGGTGTAGCTCTTGCAGATCAAATAACGTGTGTA
GACTGGCGAGCCAGAAAAGTAGAAAAGAAGGGAAAGGTTGCCACCGGAGAATTGTCAGAAATCAGAGCTAAAGCAAAAGC
CTTAATCGGTTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14650.65 Da
• Isoelectric Point: 4.4367

>AT207015 WP_032006590.1 NZ_CP077303:c2750781-2750377 [Acinetobacter pittii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASEVGKFLDDTDYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT207015 NZ_CP102842:35164-35409 [Klebsiella pneumoniae]
ATGTCACAGGCAACGTTCAAGAAATGGGGTAACCAGGCAGGAATTCGTTTTCCGGCAGCGGTGATGAAAGCAGCAGCGCT
TAACGTAGATGATACGGTTGATATTGAGGTACAGGAAGGGCGGATTGTACTCATACCAACGAAAGAAAAGACCTATTCAC
TCGATGCCTTATTATCCGGCATCACCGAAGAAAACATGCATAACAAAGCTGACTTCGGCAAACCGACAGGGAAGGAAATG
CTCTGA

Structures

Toxin

• AlphaFold DB: A0A837R0V9