Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 678395..679184 Replicon chromosome
Accession NZ_CP077302
Organism Corynebacterium coyleae strain FDAARGOS 1425

Toxin (Protein)


Gene name tacT Uniprot ID A0A1F1UW51
Locus tag I6L55_RS03220 Protein ID WP_070422117.1
Coordinates 678672..679184 (+) Length 171 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A1H4JNZ8
Locus tag I6L55_RS03215 Protein ID WP_070422119.1
Coordinates 678395..678679 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L55_RS03215 (I6L55_03215) 678395..678679 + 285 WP_070422119.1 DUF1778 domain-containing protein Antitoxin
I6L55_RS03220 (I6L55_03220) 678672..679184 + 513 WP_070422117.1 GNAT family N-acetyltransferase Toxin
I6L55_RS03225 (I6L55_03225) 679155..680240 - 1086 WP_141739371.1 hypothetical protein -
I6L55_RS03230 (I6L55_03230) 680486..681775 - 1290 WP_070451081.1 adenylosuccinate synthase -
I6L55_RS03235 (I6L55_03235) 681828..682631 + 804 WP_208856568.1 hypothetical protein -
I6L55_RS03240 (I6L55_03240) 682933..683781 + 849 WP_092100733.1 PRC and DUF2382 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(25-142)

Antitoxin

Vibrio phage ICP1, Orf50

(3-86)


Sequences

Toxin        


Download         Length: 171 a.a.        Molecular weight: 18977.63 Da        Isoelectric Point: 8.8932

>T207011 WP_070422117.1 NZ_CP077302:678672-679184 [Corynebacterium coyleae]
MTRDIIQPPRTIEKEDDVAGFSCGVESLDKWLKENAWKNQRANNSVTYVTTLNDKVVGYYALASGGVSRDALPKRFRNNR
PKDVPIILLGRFAVDSRAQGRQLGKSLLQDMFRRAIAAAEIIGAAAILIHAHDESAKQFYLHNANFHEMPGEPLHLLLPV
ESLIQQAQNS

Download         Length: 513 bp

>T207011 NZ_CP102841:c4605848-4605315 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCTGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGTATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10623.01 Da        Isoelectric Point: 4.5849

>AT207011 WP_070422119.1 NZ_CP077302:678395-678679 [Corynebacterium coyleae]
MTQPKVKRLHLRTTEVQDETLRSAAEAQDVPVSDFVLGSAMIEAEKILADRRWFELSDEDFAKFEKALDTPVDGTKLARL
LASDSVFGKEFHLD

Download         Length: 285 bp

>AT207011 NZ_CP102841:c4606125-4605859 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1F1UW51

Antitoxin

Source ID Structure
AlphaFold DB A0A1H4JNZ8

References