Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-YefM
Location 60517..61022 Replicon chromosome
Accession NZ_CP077302
Organism Corynebacterium coyleae strain FDAARGOS 1425

Toxin (Protein)


Gene name relB Uniprot ID A0A1F1UTI2
Locus tag I6L55_RS00310 Protein ID WP_070422282.1
Coordinates 60517..60771 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1F1UTG6
Locus tag I6L55_RS00315 Protein ID WP_070422281.1
Coordinates 60771..61022 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L55_RS00285 (I6L55_00285) 55934..56599 + 666 WP_092100186.1 peroxide stress protein YaaA -
I6L55_RS00290 (I6L55_00290) 56603..57424 - 822 WP_143028409.1 hypothetical protein -
I6L55_RS00295 (I6L55_00295) 57736..58458 + 723 WP_143028410.1 DUF1648 domain-containing protein -
I6L55_RS00300 (I6L55_00300) 58462..59682 - 1221 WP_070422284.1 sodium/glutamate symporter -
I6L55_RS00305 (I6L55_00305) 59792..60520 + 729 WP_070422283.1 NAD-dependent deacylase -
I6L55_RS00310 (I6L55_00310) 60517..60771 - 255 WP_070422282.1 Txe/YoeB family addiction module toxin Toxin
I6L55_RS00315 (I6L55_00315) 60771..61022 - 252 WP_070422281.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
I6L55_RS00320 (I6L55_00320) 61064..62014 - 951 WP_092100194.1 methyltransferase -
I6L55_RS00325 (I6L55_00325) 61998..62738 - 741 WP_070771436.1 uroporphyrinogen-III C-methyltransferase -
I6L55_RS00330 (I6L55_00330) 62763..63968 + 1206 WP_092100196.1 protein adenylyltransferase SelO family protein -
I6L55_RS00335 (I6L55_00335) 63996..65492 - 1497 WP_092100198.1 malate dehydrogenase (quinone) -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-67)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10039.42 Da        Isoelectric Point: 9.6972

>T207010 WP_070422282.1 NZ_CP077302:c60771-60517 [Corynebacterium coyleae]
MRLVWTTNAWEDYLYWQGNDKKTLRRVNQLLRDTLRDPFEGIGKPEPLKYGAEGAWSRRITQEHRLVYTVAGTDLVILQA
RYHY

Download         Length: 255 bp

>T207010 NZ_CP102841:3982514-3982732 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9278.27 Da        Isoelectric Point: 4.3304

>AT207010 WP_070422281.1 NZ_CP077302:c61022-60771 [Corynebacterium coyleae]
MSISASEARRTLYPLIERVNNDRDPVEIVSRHGNAVLMAADDYAAWVETAYLFKSPENARRLTQAYEEALNGAVAEHDID
LDA

Download         Length: 252 bp

>AT207010 NZ_CP102841:3982113-3982487 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1F1UTI2

Antitoxin

Source ID Structure
AlphaFold DB A0A1F1UTG6

References