Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3725395..3726015 Replicon chromosome
Accession NZ_CP077300
Organism Citrobacter braakii strain FDAARGOS 1422

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag I6L52_RS17645 Protein ID WP_002892050.1
Coordinates 3725797..3726015 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag I6L52_RS17640 Protein ID WP_003021733.1
Coordinates 3725395..3725769 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L52_RS17630 (3720542) 3720542..3721735 + 1194 WP_016152074.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
I6L52_RS17635 (3721758) 3721758..3724907 + 3150 WP_016152073.1 efflux RND transporter permease AcrB -
I6L52_RS17640 (3725395) 3725395..3725769 + 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
I6L52_RS17645 (3725797) 3725797..3726015 + 219 WP_002892050.1 HHA domain-containing protein Toxin
I6L52_RS17650 (3726196) 3726196..3726747 + 552 WP_016152072.1 maltose O-acetyltransferase -
I6L52_RS17655 (3726864) 3726864..3727334 + 471 WP_016152071.1 YlaC family protein -
I6L52_RS17660 (3727413) 3727413..3727553 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
I6L52_RS17665 (3727555) 3727555..3727815 - 261 WP_016152070.1 type B 50S ribosomal protein L31 -
I6L52_RS17670 (3728004) 3728004..3729557 + 1554 WP_094760921.1 EAL domain-containing protein -
I6L52_RS17675 (3729609) 3729609..3729962 - 354 WP_003831033.1 DUF1428 family protein -
I6L52_RS17680 (3730027) 3730027..3730656 - 630 WP_016155872.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T207007 WP_002892050.1 NZ_CP077300:3725797-3726015 [Citrobacter braakii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T207007 NZ_CP102841:1929473-1929575 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT207007 WP_003021733.1 NZ_CP077300:3725395-3725769 [Citrobacter braakii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT207007 NZ_CP102841:c1929582-1929437 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References